Evaluating the IgMi mouse as a novel tool to study B-cell biology
Research output: Contribution to journal › Letter › peer-review
Authors
Colleges, School and Institutes
External organisations
- Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science centre, The University of Manchester, Manchester, United Kingdom of Great Britain and Northern Ireland.
- Institute for Molecular Medicine, University of Mainz, Mainz, Germany.
Abstract
The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.
Bibliographic note
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 2068-2071 |
| Number of pages | 4 |
| Journal | European Journal of Immunology |
| Volume | 48 |
| Issue number | 12 |
| Early online date | 13 Oct 2018 |
| Publication status | Published - Dec 2018 |