Evaluating the IgMi mouse as a novel tool to study B-cell biology

Research output: Contribution to journalLetterpeer-review


  • Rinal Sahputra
  • Juan Carlos Yam-Puc
  • Ari Waisman
  • Werner Muller
  • Kathryn J Else

Colleges, School and Institutes

External organisations

  • Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science centre, The University of Manchester, Manchester, United Kingdom of Great Britain and Northern Ireland.
  • Institute for Molecular Medicine, University of Mainz, Mainz, Germany.


The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.

Bibliographic note

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Original languageEnglish
Pages (from-to)2068-2071
Number of pages4
JournalEuropean Journal of Immunology
Issue number12
Early online date13 Oct 2018
Publication statusPublished - Dec 2018