Evaluating the fat distribution in Idiopathic Intracranial Hypertension using Dual energy X-ray absorptiometry scanning

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Evaluating the fat distribution in Idiopathic Intracranial Hypertension using Dual energy X-ray absorptiometry scanning. / Hornby, Catherine; Botfield, Hannah; O'reilly, Michael; Westgate, Connar; Mitchell, James; Mollan, Susan; Manolopoulos, Konstantinos; Tomlinson, Jeremy ; Sinclair, Alexandra.

In: Neuro-Ophthalmology, 20.06.2017.

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@article{36889b8caf9f44438ee38373dfa329f6,
title = "Evaluating the fat distribution in Idiopathic Intracranial Hypertension using Dual energy X-ray absorptiometry scanning",
abstract = "Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients (n = 24) had a similar fat distribution to body mass index (BMI)– and gender-matched obese controls (n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (−4.40 ± 1.6%; p = 0.008) compared with the limbs (+0.79 ± 6.5%; p = 0.71). These results indicate that, contrary to previous studies using waist-hip ratios, IIH adiposity is centripetal, similar to simple obesity. Future studies should establish the risk of the metabolic syndrome and the role of adipose tissue depot–specific function in IIH.",
keywords = "DEXA, idiopathic intracranial hypertension, obesity",
author = "Catherine Hornby and Hannah Botfield and Michael O'reilly and Connar Westgate and James Mitchell and Susan Mollan and Konstantinos Manolopoulos and Jeremy Tomlinson and Alexandra Sinclair",
year = "2017",
month = jun,
day = "20",
doi = "10.1080/01658107.2017.1334218",
language = "English",
journal = "Neuro-Ophthalmology",
issn = "0165-8107",
publisher = "Informa Healthcare",

}

RIS

TY - JOUR

T1 - Evaluating the fat distribution in Idiopathic Intracranial Hypertension using Dual energy X-ray absorptiometry scanning

AU - Hornby, Catherine

AU - Botfield, Hannah

AU - O'reilly, Michael

AU - Westgate, Connar

AU - Mitchell, James

AU - Mollan, Susan

AU - Manolopoulos, Konstantinos

AU - Tomlinson, Jeremy

AU - Sinclair, Alexandra

PY - 2017/6/20

Y1 - 2017/6/20

N2 - Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients (n = 24) had a similar fat distribution to body mass index (BMI)– and gender-matched obese controls (n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (−4.40 ± 1.6%; p = 0.008) compared with the limbs (+0.79 ± 6.5%; p = 0.71). These results indicate that, contrary to previous studies using waist-hip ratios, IIH adiposity is centripetal, similar to simple obesity. Future studies should establish the risk of the metabolic syndrome and the role of adipose tissue depot–specific function in IIH.

AB - Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients (n = 24) had a similar fat distribution to body mass index (BMI)– and gender-matched obese controls (n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (−4.40 ± 1.6%; p = 0.008) compared with the limbs (+0.79 ± 6.5%; p = 0.71). These results indicate that, contrary to previous studies using waist-hip ratios, IIH adiposity is centripetal, similar to simple obesity. Future studies should establish the risk of the metabolic syndrome and the role of adipose tissue depot–specific function in IIH.

KW - DEXA

KW - idiopathic intracranial hypertension

KW - obesity

U2 - 10.1080/01658107.2017.1334218

DO - 10.1080/01658107.2017.1334218

M3 - Article

JO - Neuro-Ophthalmology

JF - Neuro-Ophthalmology

SN - 0165-8107

ER -