Establishment and functioning of intrathymic microenvironments

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Establishment and functioning of intrathymic microenvironments. / Anderson, Graham; Jenkinson, William; Jones, T; Parnell, Sonia; Kinsella, Francesca; White, Andrea; Pongrac'z, JE; Rossi, Simona; Jenkinson, Eric.

In: Immunological Reviews, Vol. 209, No. 1, 28.01.2006, p. 10-27.

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@article{8d7fbb9ed22e41b294154fcb224163db,
title = "Establishment and functioning of intrathymic microenvironments",
abstract = "The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.",
author = "Graham Anderson and William Jenkinson and T Jones and Sonia Parnell and Francesca Kinsella and Andrea White and JE Pongrac'z and Simona Rossi and Eric Jenkinson",
year = "2006",
month = jan,
day = "28",
doi = "10.1111/j.0105-2896.2006.00347.x",
language = "English",
volume = "209",
pages = "10--27",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Establishment and functioning of intrathymic microenvironments

AU - Anderson, Graham

AU - Jenkinson, William

AU - Jones, T

AU - Parnell, Sonia

AU - Kinsella, Francesca

AU - White, Andrea

AU - Pongrac'z, JE

AU - Rossi, Simona

AU - Jenkinson, Eric

PY - 2006/1/28

Y1 - 2006/1/28

N2 - The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

AB - The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

UR - http://europepmc.org/abstract/med/16448531

U2 - 10.1111/j.0105-2896.2006.00347.x

DO - 10.1111/j.0105-2896.2006.00347.x

M3 - Article

C2 - 16448531

VL - 209

SP - 10

EP - 27

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -