Establishment and functioning of intrathymic microenvironments

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Colleges, School and Institutes

Abstract

The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

Details

Original languageEnglish
Pages (from-to)10-27
JournalImmunological Reviews
Volume209
Issue number1
Publication statusPublished - 28 Jan 2006