Establishing the UK DNA Bank for motor neuron disease (MND)

Research output: Contribution to journalArticlepeer-review

Authors

  • Lucy Smith
  • B. C. Cupid
  • B. G M Dickie
  • A. Al-Chalabi
  • C. E. Shaw
  • P. J. Shaw

Colleges, School and Institutes

External organisations

  • King's College London
  • MOTOR NEURONE DISEASE ASSOCIATION
  • SHEFFIELD UNIVERSITY
  • School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand; Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
  • California Institute for Biomedical Research
  • Motor Neurone Disease Association
  • NIHR Biomedical Research Unit in Dementia
  • Sheffield Institute for Translational Neuroscience
  • University of Sheffield

Abstract

In 2003 the Motor Neurone Disease (MND) Association, together with The Wellcome Trust, funded the creation of a national DNA Bank specific for MND. It was anticipated that the DNA Bank would constitute an important resource to researchers worldwide and significantly increase activity in MND genetic research. The DNA Bank houses over 3000 high quality DNA samples, all of which were donated by people living with MND, family members and non-related controls, accompanied by clinical phenotype data about the patients. Today the primary focus of the UK MND DNA Bank still remains to identify causative and disease modifying factors for this devastating disease.

Details

Original languageEnglish
Article number84
JournalBMC Genetics
Volume16
Issue number1
Publication statusPublished - 14 Jul 2015

Keywords

  • Amyotrophic Lateral Sclerosis (ALS), Biobank, Motor Neurone Disease (MND)

ASJC Scopus subject areas