Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: Head and neck 5000

Andrew Robert Ness; Andrea Waylen; Katrina Hurley; Mona Jeffreys; Chris Penfold; Miranda Pring; Sam Leary; Christine Allmark; Stu Toms; Susan Ring; Tim J. Peters; Will Hollingworth; Helen Worthington; Chris Nutting; Sheila Fisher; Simon N. Rogers; Simon Rogers; J. K. Thiruchelvam; Maged Abdelkader; Shahram Anari; Hisham Mehanna; Tom Sheehan; Karen Dyker; James McCaul; Richard Benson; Simon Stewart; Charles Hall; Jim Lester; Jarrod Homer; Abdel Hamid; Alan Lamont; Lydia Fresco; Shane Lester; Geoffrey Cogill; Amy Roy; Bernie Foran; Brian Bisase; Alistair Balfour; Andrew Evans; Simon Gollins; David Conway; Sinnappa P. Gunasekaran; Laura Lees; Rachel Lowe; James England; Christopher Scrase; Richard Wight; Mehmet Sen; Margret Doyle; Russell Moule; Kate Goodchild; Nick Rowell; Dawn Beaumont-Jewell; H. W. Loo; Petra Jankowska; Vinidh Paleri; Richard Casasola; Tom Roques; Paul Tierney; David Hwang; P. Dyson; Gerard Andrade; Taran Tatla; Judith Christian; Stuart Winter; Andrew Baldwin; Joe Davies; Emma King; Debi Barnes; Costas Repanos; Dae Kim; Stuart Richards; Nicola Dallas; Ken McAlister; Sandeep Berry; Naomi Cole; Laura Moss; Nachi Palaniappan; Mererid Evans; Muthu Siva; Churunal Hari; Katie Wood; Richard Simcock; John Waldron; Nicholas Hyde; Imtiaz Ahmed; Daljit Gahir; James O'Hara; Ruth Carr; Martin Forster; Steve Thomas; Lynda Wagstaff; Joseph Mano; Caroline Brammer; Jayne Tyler; Andrew Coatesworth; Steve Thomas

doi:10.1186/1471-2407-14-973

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: Head and neck 5000

Andrew Robert Ness^*, Andrea Waylen, Katrina Hurley, Mona Jeffreys, Chris Penfold, Miranda Pring, Sam Leary, Christine Allmark, Stu Toms, Susan Ring, Tim J. Peters, Will Hollingworth, Helen Worthington, Chris Nutting, Sheila Fisher, Simon N. Rogers, Simon Rogers, J. K. Thiruchelvam, Maged Abdelkader, Shahram AnariHisham Mehanna, Tom Sheehan, Karen Dyker, James McCaul, Richard Benson, Simon Stewart, Charles Hall, Jim Lester, Jarrod Homer, Abdel Hamid, Alan Lamont, Lydia Fresco, Shane Lester, Geoffrey Cogill, Amy Roy, Bernie Foran, Brian Bisase, Alistair Balfour, Andrew Evans, Simon Gollins, David Conway, Sinnappa P. Gunasekaran, Laura Lees, Rachel Lowe, James England, Christopher Scrase, Richard Wight, Mehmet Sen, Margret Doyle, Russell Moule, Kate Goodchild, Nick Rowell, Dawn Beaumont-Jewell, H. W. Loo, Petra Jankowska, Vinidh Paleri, Richard Casasola, Tom Roques, Paul Tierney, David Hwang, P. Dyson, Gerard Andrade, Taran Tatla, Judith Christian, Stuart Winter, Andrew Baldwin, Joe Davies, Emma King, Debi Barnes, Costas Repanos, Dae Kim, Stuart Richards, Nicola Dallas, Ken McAlister, Sandeep Berry, Naomi Cole, Laura Moss, Nachi Palaniappan, Mererid Evans, Muthu Siva, Churunal Hari, Katie Wood, Richard Simcock, John Waldron, Nicholas Hyde, Imtiaz Ahmed, Daljit Gahir, James O'Hara, Ruth Carr, Martin Forster, Steve Thomas, Lynda Wagstaff, Joseph Mano, Caroline Brammer, Jayne Tyler, Andrew Coatesworth, Steve Thomas

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors.

METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires.

DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.

Original language	English
Article number	973
Pages (from-to)	973
Journal	BMC Cancer
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/1471-2407-14-973 https://doi.org/10.1186/1471-2407-14-973
Publication status	Published - 17 Dec 2014

Keywords

Data Collection
Great Britain
Head and Neck Neoplasms
Humans
Informed Consent
Life Style
Longitudinal Studies
Medical Record Linkage
Patient Selection
Prognosis
Prospective Studies
Quality of Life
Sexual Behavior
Surveys and Questionnaires
Translational Medical Research

ASJC Scopus subject areas

Oncology
Cancer Research
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Ness, A. R., Waylen, A., Hurley, K., Jeffreys, M., Penfold, C., Pring, M., Leary, S., Allmark, C., Toms, S., Ring, S., Peters, T. J., Hollingworth, W., Worthington, H., Nutting, C., Fisher, S., Rogers, S. N., Rogers, S., Thiruchelvam, J. K., Abdelkader, M., ... Thomas, S. (2014). Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: Head and neck 5000. BMC Cancer, 14(1), 973. Article 973. https://doi.org/10.1186/1471-2407-14-973, https://doi.org/10.1186/1471-2407-14-973

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title = "Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: Head and neck 5000",

abstract = "BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors.METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires.DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.",

keywords = "Data Collection, Great Britain, Head and Neck Neoplasms, Humans, Informed Consent, Life Style, Longitudinal Studies, Medical Record Linkage, Patient Selection, Prognosis, Prospective Studies, Quality of Life, Sexual Behavior, Surveys and Questionnaires, Translational Medical Research",

author = "Ness, {Andrew Robert} and Andrea Waylen and Katrina Hurley and Mona Jeffreys and Chris Penfold and Miranda Pring and Sam Leary and Christine Allmark and Stu Toms and Susan Ring and Peters, {Tim J.} and Will Hollingworth and Helen Worthington and Chris Nutting and Sheila Fisher and Rogers, {Simon N.} and Simon Rogers and Thiruchelvam, {J. K.} and Maged Abdelkader and Shahram Anari and Hisham Mehanna and Tom Sheehan and Karen Dyker and James McCaul and Richard Benson and Simon Stewart and Charles Hall and Jim Lester and Jarrod Homer and Abdel Hamid and Alan Lamont and Lydia Fresco and Shane Lester and Geoffrey Cogill and Amy Roy and Bernie Foran and Brian Bisase and Alistair Balfour and Andrew Evans and Simon Gollins and David Conway and Gunasekaran, {Sinnappa P.} and Laura Lees and Rachel Lowe and James England and Christopher Scrase and Richard Wight and Mehmet Sen and Margret Doyle and Russell Moule and Kate Goodchild and Nick Rowell and Dawn Beaumont-Jewell and Loo, {H. W.} and Petra Jankowska and Vinidh Paleri and Richard Casasola and Tom Roques and Paul Tierney and David Hwang and P. Dyson and Gerard Andrade and Taran Tatla and Judith Christian and Stuart Winter and Andrew Baldwin and Joe Davies and Emma King and Debi Barnes and Costas Repanos and Dae Kim and Stuart Richards and Nicola Dallas and Ken McAlister and Sandeep Berry and Naomi Cole and Laura Moss and Nachi Palaniappan and Mererid Evans and Muthu Siva and Churunal Hari and Katie Wood and Richard Simcock and John Waldron and Nicholas Hyde and Imtiaz Ahmed and Daljit Gahir and James O'Hara and Ruth Carr and Martin Forster and Steve Thomas and Lynda Wagstaff and Joseph Mano and Caroline Brammer and Jayne Tyler and Andrew Coatesworth and Steve Thomas",

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Ness, AR, Waylen, A, Hurley, K, Jeffreys, M, Penfold, C, Pring, M, Leary, S, Allmark, C, Toms, S, Ring, S, Peters, TJ, Hollingworth, W, Worthington, H, Nutting, C, Fisher, S, Rogers, SN, Rogers, S, Thiruchelvam, JK, Abdelkader, M, Anari, S, Mehanna, H, Sheehan, T, Dyker, K, McCaul, J, Benson, R, Stewart, S, Hall, C, Lester, J, Homer, J, Hamid, A, Lamont, A, Fresco, L, Lester, S, Cogill, G, Roy, A, Foran, B, Bisase, B, Balfour, A, Evans, A, Gollins, S, Conway, D, Gunasekaran, SP, Lees, L, Lowe, R, England, J, Scrase, C, Wight, R, Sen, M, Doyle, M, Moule, R, Goodchild, K, Rowell, N, Beaumont-Jewell, D, Loo, HW, Jankowska, P, Paleri, V, Casasola, R, Roques, T, Tierney, P, Hwang, D, Dyson, P, Andrade, G, Tatla, T, Christian, J, Winter, S, Baldwin, A, Davies, J, King, E, Barnes, D, Repanos, C, Kim, D, Richards, S, Dallas, N, McAlister, K, Berry, S, Cole, N, Moss, L, Palaniappan, N, Evans, M, Siva, M, Hari, C, Wood, K, Simcock, R, Waldron, J, Hyde, N, Ahmed, I, Gahir, D, O'Hara, J, Carr, R, Forster, M, Thomas, S, Wagstaff, L, Mano, J, Brammer, C, Tyler, J, Coatesworth, A & Thomas, S 2014, 'Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: Head and neck 5000', BMC Cancer, vol. 14, no. 1, 973, pp. 973. https://doi.org/10.1186/1471-2407-14-973, https://doi.org/10.1186/1471-2407-14-973

TY - JOUR

T1 - Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource

T2 - Head and neck 5000

AU - Ness, Andrew Robert

AU - Waylen, Andrea

AU - Hurley, Katrina

AU - Jeffreys, Mona

AU - Penfold, Chris

AU - Pring, Miranda

AU - Leary, Sam

AU - Allmark, Christine

AU - Toms, Stu

AU - Ring, Susan

AU - Peters, Tim J.

AU - Hollingworth, Will

AU - Worthington, Helen

AU - Nutting, Chris

AU - Fisher, Sheila

AU - Rogers, Simon N.

AU - Rogers, Simon

AU - Thiruchelvam, J. K.

AU - Abdelkader, Maged

AU - Anari, Shahram

AU - Mehanna, Hisham

AU - Sheehan, Tom

AU - Dyker, Karen

AU - McCaul, James

AU - Benson, Richard

AU - Stewart, Simon

AU - Hall, Charles

AU - Lester, Jim

AU - Homer, Jarrod

AU - Hamid, Abdel

AU - Lamont, Alan

AU - Fresco, Lydia

AU - Lester, Shane

AU - Cogill, Geoffrey

AU - Roy, Amy

AU - Foran, Bernie

AU - Bisase, Brian

AU - Balfour, Alistair

AU - Evans, Andrew

AU - Gollins, Simon

AU - Conway, David

AU - Gunasekaran, Sinnappa P.

AU - Lees, Laura

AU - Lowe, Rachel

AU - England, James

AU - Scrase, Christopher

AU - Wight, Richard

AU - Sen, Mehmet

AU - Doyle, Margret

AU - Moule, Russell

AU - Goodchild, Kate

AU - Rowell, Nick

AU - Beaumont-Jewell, Dawn

AU - Loo, H. W.

AU - Jankowska, Petra

AU - Paleri, Vinidh

AU - Casasola, Richard

AU - Roques, Tom

AU - Tierney, Paul

AU - Hwang, David

AU - Dyson, P.

AU - Andrade, Gerard

AU - Tatla, Taran

AU - Christian, Judith

AU - Winter, Stuart

AU - Baldwin, Andrew

AU - Davies, Joe

AU - King, Emma

AU - Barnes, Debi

AU - Repanos, Costas

AU - Kim, Dae

AU - Richards, Stuart

AU - Dallas, Nicola

AU - McAlister, Ken

AU - Berry, Sandeep

AU - Cole, Naomi

AU - Moss, Laura

AU - Palaniappan, Nachi

AU - Evans, Mererid

AU - Siva, Muthu

AU - Hari, Churunal

AU - Wood, Katie

AU - Simcock, Richard

AU - Waldron, John

AU - Hyde, Nicholas

AU - Ahmed, Imtiaz

AU - Gahir, Daljit

AU - O'Hara, James

AU - Carr, Ruth

AU - Forster, Martin

AU - Thomas, Steve

AU - Wagstaff, Lynda

AU - Mano, Joseph

AU - Brammer, Caroline

AU - Tyler, Jayne

AU - Coatesworth, Andrew

AU - Thomas, Steve

PY - 2014/12/17

Y1 - 2014/12/17

N2 - BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors.METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires.DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.

AB - BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors.METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires.DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.

KW - Data Collection

KW - Great Britain

KW - Head and Neck Neoplasms

KW - Humans

KW - Informed Consent

KW - Life Style

KW - Longitudinal Studies

KW - Medical Record Linkage

KW - Patient Selection

KW - Prognosis

KW - Prospective Studies

KW - Quality of Life

KW - Sexual Behavior

KW - Surveys and Questionnaires

KW - Translational Medical Research

UR - http://www.scopus.com/inward/record.url?scp=84924801922&partnerID=8YFLogxK

U2 - 10.1186/1471-2407-14-973

DO - 10.1186/1471-2407-14-973

M3 - Article

C2 - 25519023

AN - SCOPUS:84924801922

SN - 1471-2407

VL - 14

SP - 973

JO - BMC Cancer

JF - BMC Cancer

IS - 1

M1 - 973

ER -

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: Head and neck 5000

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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