Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: Head and neck 5000

Research output: Contribution to journalArticlepeer-review


  • Andrew Robert Ness
  • Andrea Waylen
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Colleges, School and Institutes

External organisations

  • Gloucestershire Hospitals NHS Foundation Trust
  • University of Bristol
  • National Cancer Research Institute Consumer Liaison Group (NCRI CLG)
  • University of Manchester
  • Royal Marsden Hospital, Sutton, UK.
  • University of Leeds
  • Edge Hill University
  • Birmingham Heartlands & Solihull NHS Trust
  • Birmingham QEH
  • United Lincolnshire Hospital
  • St. George's Healthcare National Health Service Trust
  • Gloucestershire Royal Hospital
  • Chesterfield Royal Hospital
  • Royal Manchester Childrens Hosp
  • Stoke City General
  • Darlington Memorial Hospital
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  • Scunthorpe General Hospital
  • Wye Valley NHS Trust
  • Lister Hospital, East and North Hertfordshire NHS Trust
  • Mid Essex Hospital
  • Musgrove Park
  • Ninewells Hospital
  • North Bristol NHS Trust
  • Royal Devon and Exeter Hospital
  • Nottingham University Hospitals NHS Trust
  • Royal Berkshire Hospital
  • Royal Blackburn Hosp
  • Royal Glamorgan Hosp
  • Royal Gwent Hospital
  • U H Wales
  • Royal Preston Hospital Lancashire Teaching Hospitals NHS Foundation Trust
  • Royal Shrewsbury and Telford Hospital NHS Trust
  • Royal Surrey County Hospital
  • Royal West Sussex Trust
  • Royal United Hospitals Bath
  • Sunderland Royal Hospital
  • UCL
  • U H Bristol
  • Birmingham QEH
  • Blackburn Royal Infirm
  • Royal Glamorgan Hosp
  • Manchester Royal Infirm
  • Royal Marsden Hospital, London
  • Stoke City General
  • U H Bristol
  • U H Wales


BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors.

METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires.

DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.


Original languageEnglish
Article number973
Pages (from-to)973
JournalBMC Cancer
Issue number1
Publication statusPublished - 17 Dec 2014


  • Data Collection, Great Britain, Head and Neck Neoplasms, Humans, Informed Consent, Life Style, Longitudinal Studies, Medical Record Linkage, Patient Selection, Prognosis, Prospective Studies, Quality of Life, Sexual Behavior, Surveys and Questionnaires, Translational Medical Research

ASJC Scopus subject areas