Abstract
EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via its amino-terminal SH3 region. Coimmunoprecipitation and confocal microscopy showed specific EspF-SNX9 interaction and nonmitochondrial protein colocalization in infected epithelial cells.
Original language | English |
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Pages (from-to) | 3110-3115 |
Number of pages | 6 |
Journal | Journal of Bacteriology |
Volume | 188 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Apr 2006 |