Ergogenic effects of an epidural neuroprosthesis in one individual with spinal cord injury

Tom E Nightingale; Matthias Walter; Alison M M Williams; Tania Lam; Andrei V Krassioukov

doi:10.1212/WNL.0000000000006923

Ergogenic effects of an epidural neuroprosthesis in one individual with spinal cord injury

Tom E Nightingale, Matthias Walter, Alison M M Williams, Tania Lam, Andrei V Krassioukov

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

133 Downloads (Pure)

Abstract

Individuals with a spinal cord injury (SCI) ≥T6 level exhibit impaired cardiovascular responses to exercise that can limit exercise capacity.1 The burgeoning field of neuromodulation has recently demonstrated that epidural spinal cord stimulation (ESCS), configured to facilitate motor function in humans with SCI, can also modulate cardiovascular function (i.e., increasing or maintaining arterial blood pressure at rest or in response to an orthostatic challenge, respectively).2,–,4 Here we present a unique application of ESCS to improve upper body exercise capacity in an individual with SCI, via the modulation of cardiovascular and respiratory function.

Original language	English
Pages (from-to)	338-340
Number of pages	3
Journal	Neurology
Volume	92
Issue number	7
Early online date	11 Jan 2019
DOIs	https://doi.org/10.1212/WNL.0000000000006923
Publication status	Published - 12 Feb 2019

Keywords

Adult
Arterial Pressure
Blood Pressure
Exercise
Humans
Implantable Neurostimulators
Male
Oxygen Consumption
Physical Exertion
Quadriplegia/physiopathology
Respiration
Spinal Cord Injuries/physiopathology
Spinal Cord Stimulation/methods
Stroke Volume

Access to Document

10.1212/WNL.0000000000006923Licence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

nightingalet2019ergogenicFinal published version, 359 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

https://doi.org/10.1212/WNL.0000000000006923Licence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Cite this

@article{8ff36ee9e05f4c8aa3b27298dcfd3a61,

title = "Ergogenic effects of an epidural neuroprosthesis in one individual with spinal cord injury",

abstract = "Individuals with a spinal cord injury (SCI) ≥T6 level exhibit impaired cardiovascular responses to exercise that can limit exercise capacity.1 The burgeoning field of neuromodulation has recently demonstrated that epidural spinal cord stimulation (ESCS), configured to facilitate motor function in humans with SCI, can also modulate cardiovascular function (i.e., increasing or maintaining arterial blood pressure at rest or in response to an orthostatic challenge, respectively).2,–,4 Here we present a unique application of ESCS to improve upper body exercise capacity in an individual with SCI, via the modulation of cardiovascular and respiratory function.",

keywords = "Adult, Arterial Pressure, Blood Pressure, Exercise, Humans, Implantable Neurostimulators, Male, Oxygen Consumption, Physical Exertion, Quadriplegia/physiopathology, Respiration, Spinal Cord Injuries/physiopathology, Spinal Cord Stimulation/methods, Stroke Volume",

author = "Nightingale, {Tom E} and Matthias Walter and Williams, {Alison M M} and Tania Lam and Krassioukov, {Andrei V}",

year = "2019",

month = feb,

day = "12",

doi = "10.1212/WNL.0000000000006923",

language = "English",

volume = "92",

pages = "338--340",

journal = "Neurology",

issn = "0028-3878",

publisher = "American Academy of Neurology",

number = "7",

}

TY - JOUR

T1 - Ergogenic effects of an epidural neuroprosthesis in one individual with spinal cord injury

AU - Nightingale, Tom E

AU - Walter, Matthias

AU - Williams, Alison M M

AU - Lam, Tania

AU - Krassioukov, Andrei V

PY - 2019/2/12

Y1 - 2019/2/12

N2 - Individuals with a spinal cord injury (SCI) ≥T6 level exhibit impaired cardiovascular responses to exercise that can limit exercise capacity.1 The burgeoning field of neuromodulation has recently demonstrated that epidural spinal cord stimulation (ESCS), configured to facilitate motor function in humans with SCI, can also modulate cardiovascular function (i.e., increasing or maintaining arterial blood pressure at rest or in response to an orthostatic challenge, respectively).2,–,4 Here we present a unique application of ESCS to improve upper body exercise capacity in an individual with SCI, via the modulation of cardiovascular and respiratory function.

AB - Individuals with a spinal cord injury (SCI) ≥T6 level exhibit impaired cardiovascular responses to exercise that can limit exercise capacity.1 The burgeoning field of neuromodulation has recently demonstrated that epidural spinal cord stimulation (ESCS), configured to facilitate motor function in humans with SCI, can also modulate cardiovascular function (i.e., increasing or maintaining arterial blood pressure at rest or in response to an orthostatic challenge, respectively).2,–,4 Here we present a unique application of ESCS to improve upper body exercise capacity in an individual with SCI, via the modulation of cardiovascular and respiratory function.

KW - Adult

KW - Arterial Pressure

KW - Blood Pressure

KW - Exercise

KW - Humans

KW - Implantable Neurostimulators

KW - Male

KW - Oxygen Consumption

KW - Physical Exertion

KW - Quadriplegia/physiopathology

KW - Respiration

KW - Spinal Cord Injuries/physiopathology

KW - Spinal Cord Stimulation/methods

KW - Stroke Volume

U2 - 10.1212/WNL.0000000000006923

DO - 10.1212/WNL.0000000000006923

M3 - Article

C2 - 30635485

SN - 0028-3878

VL - 92

SP - 338

EP - 340

JO - Neurology

JF - Neurology

IS - 7

ER -

Ergogenic effects of an epidural neuroprosthesis in one individual with spinal cord injury

Abstract

Keywords

Access to Document

Fingerprint

Cite this