Equal rights in autoimmunity: is Sjögren`s syndrome ever ‘secondary’?

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Equal rights in autoimmunity: is Sjögren`s syndrome ever ‘secondary’? / Kollert, Florian; Fisher, Benjamin.

In: Rheumatology, 05.02.2020.

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@article{e5df39dc36ab41609d6591251c243329,
title = "Equal rights in autoimmunity: is Sj{\"o}gren`s syndrome ever {\textquoteleft}secondary{\textquoteright}?",
abstract = "Sj{\"o}gren{\textquoteright}s syndrome (SjS) accompanied by other systemic autoimmune rheumatic connective tissue diseases has historically been termed {\textquoteleft}secondary{\textquoteright} in contrast to {\textquoteleft}primary{\textquoteright} SjS as a standalone entity. However it is a matter of a long-standing debate whether the prefixes {\textquoteleft}primary{\textquoteright} and {\textquoteleft}secondary{\textquoteright}, notably including a temporal component, are obsolete in the terminology of SjS. We review the history and the pathophysiological, chronological, genetic, histological and clinical data underlying the concept of {\textquoteleft}secondary{\textquoteright} SjS. There are important unintended consequences of the nomenclature; notably {\textquoteleft}secondary{\textquoteright} SjS has been much less researched and is often excluded from clinical trials. We argue for further research, a change in terminology and more stringent classification. Further we highlight possible opportunities for trials in SjS and other systemic autoimmune diseases that might contribute to an advance in care for all patients with SjS.",
keywords = "Sj{\"o}gren{\textquoteright}s syndrome, RA, SLE, systemic sclerosis, clinical trials, anti-Ro antibodies, genetics, histology, salivary glands",
author = "Florian Kollert and Benjamin Fisher",
year = "2020",
month = feb
day = "5",
doi = "10.1093/rheumatology/keaa009",
language = "English",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Equal rights in autoimmunity: is Sjögren`s syndrome ever ‘secondary’?

AU - Kollert, Florian

AU - Fisher, Benjamin

PY - 2020/2/5

Y1 - 2020/2/5

N2 - Sjögren’s syndrome (SjS) accompanied by other systemic autoimmune rheumatic connective tissue diseases has historically been termed ‘secondary’ in contrast to ‘primary’ SjS as a standalone entity. However it is a matter of a long-standing debate whether the prefixes ‘primary’ and ‘secondary’, notably including a temporal component, are obsolete in the terminology of SjS. We review the history and the pathophysiological, chronological, genetic, histological and clinical data underlying the concept of ‘secondary’ SjS. There are important unintended consequences of the nomenclature; notably ‘secondary’ SjS has been much less researched and is often excluded from clinical trials. We argue for further research, a change in terminology and more stringent classification. Further we highlight possible opportunities for trials in SjS and other systemic autoimmune diseases that might contribute to an advance in care for all patients with SjS.

AB - Sjögren’s syndrome (SjS) accompanied by other systemic autoimmune rheumatic connective tissue diseases has historically been termed ‘secondary’ in contrast to ‘primary’ SjS as a standalone entity. However it is a matter of a long-standing debate whether the prefixes ‘primary’ and ‘secondary’, notably including a temporal component, are obsolete in the terminology of SjS. We review the history and the pathophysiological, chronological, genetic, histological and clinical data underlying the concept of ‘secondary’ SjS. There are important unintended consequences of the nomenclature; notably ‘secondary’ SjS has been much less researched and is often excluded from clinical trials. We argue for further research, a change in terminology and more stringent classification. Further we highlight possible opportunities for trials in SjS and other systemic autoimmune diseases that might contribute to an advance in care for all patients with SjS.

KW - Sjögren’s syndrome

KW - RA

KW - SLE

KW - systemic sclerosis

KW - clinical trials

KW - anti-Ro antibodies

KW - genetics

KW - histology

KW - salivary glands

U2 - 10.1093/rheumatology/keaa009

DO - 10.1093/rheumatology/keaa009

M3 - Review article

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

M1 - keaa009

ER -