Epstein-Barr virus-associated lymphomas

Research output: Contribution to journalArticle

Abstract

Epstein-Barr virus (EBV), originally discovered through its association with Burkitt lymphoma, is now aetiologically linked to a remarkably wide range of lymphoproliferative lesions and malignant lymphomas of B-, T- and NK-cell origin. Some occur as rare accidents of virus persistence in the B lymphoid system, while others arise as a result of viral entry into unnatural target cells. The early finding that EBV is a potent B cell growth transforming agent hinted at a simple oncogenic mechanism by which this virus could promote lymphomagenesis. In reality, the pathogenesis of EBV-associated lymphomas involves a complex interplay between different patterns of viral gene expression and cellular genetic changes. Here we review recent developments in our understanding of EBV-associated lymphomagenesis in both the immunocompetent and immunocompromised host.

Details

Original languageEnglish
Article number20160271
JournalPhilosophical Transactions of the Royal Society of London Series B
Volume372
Issue number1732
Publication statusPublished - 11 Sep 2017

Keywords

  • Epstein-Barr virus