Epithelial-mesenchymal transition in lung development and disease: does it exist and is it important?

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Epithelial-mesenchymal transition in lung development and disease : does it exist and is it important? / Bartis, Domokos; Mise, Nikica; Mahida, Rahul Y; Eickelberg, Oliver; Thickett, David R.

In: Thorax, Vol. 69, No. 8, 12.12.2013, p. 760-765.

Research output: Contribution to journalReview articlepeer-review

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@article{fb6a2fb9e4694c1187efac0ff940042d,
title = "Epithelial-mesenchymal transition in lung development and disease: does it exist and is it important?",
abstract = "Epithelial-mesenchymal transition (EMT) is a process when epithelial cells gradually transform into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT is thought to be involved in the pathogenesis of numerous lung diseases ranging from developmental disorders, fibrotic tissue remodelling to lung cancer. The most important question--namely what is the importance and contribution of EMT in the pathogenesis of several chronic lung conditions (asthma, COPD, bronchiolitis obliterans syndrome and lung fibrosis)--is currently intensely debated. This review gives a brief insight into the mechanism and assessment methods of EMT in various pulmonary diseases and summarises the recent literature highlighting the controversial experimental data and conclusions.",
keywords = "Epithelial-Mesenchymal Transition, Humans, Lung, Lung Diseases, Transcription Factors",
author = "Domokos Bartis and Nikica Mise and Mahida, {Rahul Y} and Oliver Eickelberg and Thickett, {David R}",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2013",
month = dec,
day = "12",
doi = "10.1136/thoraxjnl-2013-204608",
language = "English",
volume = "69",
pages = "760--765",
journal = "Thorax",
issn = "0040-6376",
publisher = "BMJ Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Epithelial-mesenchymal transition in lung development and disease

T2 - does it exist and is it important?

AU - Bartis, Domokos

AU - Mise, Nikica

AU - Mahida, Rahul Y

AU - Eickelberg, Oliver

AU - Thickett, David R

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2013/12/12

Y1 - 2013/12/12

N2 - Epithelial-mesenchymal transition (EMT) is a process when epithelial cells gradually transform into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT is thought to be involved in the pathogenesis of numerous lung diseases ranging from developmental disorders, fibrotic tissue remodelling to lung cancer. The most important question--namely what is the importance and contribution of EMT in the pathogenesis of several chronic lung conditions (asthma, COPD, bronchiolitis obliterans syndrome and lung fibrosis)--is currently intensely debated. This review gives a brief insight into the mechanism and assessment methods of EMT in various pulmonary diseases and summarises the recent literature highlighting the controversial experimental data and conclusions.

AB - Epithelial-mesenchymal transition (EMT) is a process when epithelial cells gradually transform into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT is thought to be involved in the pathogenesis of numerous lung diseases ranging from developmental disorders, fibrotic tissue remodelling to lung cancer. The most important question--namely what is the importance and contribution of EMT in the pathogenesis of several chronic lung conditions (asthma, COPD, bronchiolitis obliterans syndrome and lung fibrosis)--is currently intensely debated. This review gives a brief insight into the mechanism and assessment methods of EMT in various pulmonary diseases and summarises the recent literature highlighting the controversial experimental data and conclusions.

KW - Epithelial-Mesenchymal Transition

KW - Humans

KW - Lung

KW - Lung Diseases

KW - Transcription Factors

U2 - 10.1136/thoraxjnl-2013-204608

DO - 10.1136/thoraxjnl-2013-204608

M3 - Review article

C2 - 24334519

VL - 69

SP - 760

EP - 765

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 8

ER -