Epithelial tumours induced by a herpesvirus oncogene in transgenic mice
Research output: Contribution to journal › Article
Colleges, School and Institutes
To investigate the role of herpesviral genes in tumourigenesis, transgenic mice were generated expressing STP-C, a transformation associated protein of the lymphoma inducing herpesvirus saimiri. Epithelial tumours developed in the salivary gland, pancreas, thymus and liver of transgenic mice within the first weeks of life. Thus, the target cells for tumour formation in the transgenic mice were surprisingly different from those of the herpesvirus from which the oncogene was derived. Our results identify STP-C as a herpesvirus oncogene sufficient for tumour induction without the cooperation of other viral gene products. Furthermore, the results demonstrate pleiotropic transforming capabilities of the STP-C oncogene and suggest that the specificity of lymphoma induction by the virus is determined by factors other than the oncogene itself.
M1 - 1 Murphy, C Kretschmer, C Biesinger, B Beckers, J Jung, J Desrosiers, R C Muller-Hermelink, H K Fleckenstein, B W Ruther, U eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. ENGLAND 1994/01/01 Oncogene. 1994 Jan;9(1):221-6.
|Number of pages||6|
|Publication status||Published - 1994|
- Animals Base Sequence *Cell Transformation, Neoplastic Epithelium/pathology Herpesvirus 2, Saimiriine/*genetics Lymphocyte Activation Mice Mice, Transgenic Molecular Sequence Data Neoplasms/*etiology Oncogene Proteins, Viral/*genetics *Oncogenes Phenotype