Epigenetic mechanisms regulating normal and malignant haematopoiesis: new therapeutic targets for clinical medicine

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

Abstract

It is now well established that epigenetic phenomena and aberrant gene regulation play a major role in carcinogenesis. These include aberrant gene silencing by imposing inactive histone marks on promoters, aberrant methylation of DNA at CpG islands, and the active repression of promoters by oncoproteins. In addition, many malignant cells also show aberrant gene activation due to constitutively active signalling. The next frontier in cancer research will be to examine how, at the molecular level, small mutations that alter the regulatory phenotype of a cell give rise after a number of cell divisions to the vast deregulation phenomena seen in malignant cells. This review outlines recent insights into how normal cell differentiation in the haematopoietic system is subverted in leukaemia and it introduces the molecular players involved in this process. It also summarises the results of recent clinical trials trying to reverse aberrant epigenetic regulation by employing agents influencing global epigenetic regulators.

Details

Original languageEnglish
Pages (from-to)e6
JournalExpert Reviews in Molecular Medicine
Volume12
Publication statusPublished - 1 Jan 2010

Keywords

  • epigenetic mechanisms, malignant haematopoiesis