Epidemiology and risk factors for bipolar disorder

Research output: Contribution to journalReview articlepeer-review

Standard

Epidemiology and risk factors for bipolar disorder. / Rowland, Tobias A; Marwaha, Steven.

In: Therapeutic advances in psychopharmacology, Vol. 8, No. 9, 09.2018, p. 251-269.

Research output: Contribution to journalReview articlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{0caff098ede645199b43afad2ac1959a,
title = "Epidemiology and risk factors for bipolar disorder",
abstract = "Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential risk factors enables clinicians to identify patients who are more likely to develop bipolar disorder, which directs further investigation, follow up and caution when prescribing. Ideally, identifying directly causative factors for bipolar disorder would enable intervention on an individual or population level to prevent the development of the illness, and improve outcomes through earlier treatment. This article reviews the epidemiology of bipolar disorder, along with putative demographic, genetic and environmental risk factors, while assessing the strength of these associations and to what extent they might be said to be 'causative'. While numerous genetic and environmental risk factors have been identified, the attributable risk of individual factors is often small, and most are not specific to bipolar disorder but are associated with several mental illnesses. Therefore, while some genetic and environmental factors have strong evidence supporting their association with bipolar disorder, fewer have sufficient evidence to establish causality. There is increasing interest in the role of specific gene-environment interactions, as well as the mechanisms by which risk factors interact to lead to bipolar disorder.",
author = "Rowland, {Tobias A} and Steven Marwaha",
year = "2018",
month = sep,
doi = "10.1177/2045125318769235",
language = "English",
volume = "8",
pages = "251--269",
journal = "Therapeutic advances in psychopharmacology",
issn = "2045-1253",
publisher = "SAGE Publications",
number = "9",

}

RIS

TY - JOUR

T1 - Epidemiology and risk factors for bipolar disorder

AU - Rowland, Tobias A

AU - Marwaha, Steven

PY - 2018/9

Y1 - 2018/9

N2 - Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential risk factors enables clinicians to identify patients who are more likely to develop bipolar disorder, which directs further investigation, follow up and caution when prescribing. Ideally, identifying directly causative factors for bipolar disorder would enable intervention on an individual or population level to prevent the development of the illness, and improve outcomes through earlier treatment. This article reviews the epidemiology of bipolar disorder, along with putative demographic, genetic and environmental risk factors, while assessing the strength of these associations and to what extent they might be said to be 'causative'. While numerous genetic and environmental risk factors have been identified, the attributable risk of individual factors is often small, and most are not specific to bipolar disorder but are associated with several mental illnesses. Therefore, while some genetic and environmental factors have strong evidence supporting their association with bipolar disorder, fewer have sufficient evidence to establish causality. There is increasing interest in the role of specific gene-environment interactions, as well as the mechanisms by which risk factors interact to lead to bipolar disorder.

AB - Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential risk factors enables clinicians to identify patients who are more likely to develop bipolar disorder, which directs further investigation, follow up and caution when prescribing. Ideally, identifying directly causative factors for bipolar disorder would enable intervention on an individual or population level to prevent the development of the illness, and improve outcomes through earlier treatment. This article reviews the epidemiology of bipolar disorder, along with putative demographic, genetic and environmental risk factors, while assessing the strength of these associations and to what extent they might be said to be 'causative'. While numerous genetic and environmental risk factors have been identified, the attributable risk of individual factors is often small, and most are not specific to bipolar disorder but are associated with several mental illnesses. Therefore, while some genetic and environmental factors have strong evidence supporting their association with bipolar disorder, fewer have sufficient evidence to establish causality. There is increasing interest in the role of specific gene-environment interactions, as well as the mechanisms by which risk factors interact to lead to bipolar disorder.

U2 - 10.1177/2045125318769235

DO - 10.1177/2045125318769235

M3 - Review article

C2 - 30181867

VL - 8

SP - 251

EP - 269

JO - Therapeutic advances in psychopharmacology

JF - Therapeutic advances in psychopharmacology

SN - 2045-1253

IS - 9

ER -