Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence

Odile B Harrison; Nicholas J Evans; Jessica M Blair; Holly S Grimes; Colin R Tinsley; Xavier Nassif; Paula Kriz; Roisin Ure; Steve J Gray; Jeremy P Derrick; Martin C J Maiden; Ian M Feavers

doi:10.1086/599377

Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence

Odile B Harrison, Nicholas J Evans, Jessica M Blair, Holly S Grimes, Colin R Tinsley, Xavier Nassif, Paula Kriz, Roisin Ure, Steve J Gray, Jeremy P Derrick, Martin C J Maiden, Ian M Feavers

Immunology and Immunotherapy

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28 Citations (Scopus)

Abstract

The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.

Original language	English
Pages (from-to)	94-8
Number of pages	5
Journal	The Journal of Infectious Diseases
Volume	200
Issue number	1
DOIs	https://doi.org/10.1086/599377
Publication status	Published - 1 Jul 2009

Keywords

Bacterial Proteins
DNA Primers
Humans
Meningococcal Infections
Neisseria gonorrhoeae
Neisseria lactamica
Neisseria meningitidis
Receptors, Cell Surface
Virulence

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title = "Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence",

abstract = "The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a {"}pseudo hmbR{"} gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.",

keywords = "Bacterial Proteins, DNA Primers, Humans, Meningococcal Infections, Neisseria gonorrhoeae, Neisseria lactamica, Neisseria meningitidis, Receptors, Cell Surface, Virulence",

author = "Harrison, {Odile B} and Evans, {Nicholas J} and Blair, {Jessica M} and Grimes, {Holly S} and Tinsley, {Colin R} and Xavier Nassif and Paula Kriz and Roisin Ure and Gray, {Steve J} and Derrick, {Jeremy P} and Maiden, {Martin C J} and Feavers, {Ian M}",

year = "2009",

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doi = "10.1086/599377",

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T1 - Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence

AU - Harrison, Odile B

AU - Evans, Nicholas J

AU - Blair, Jessica M

AU - Grimes, Holly S

AU - Tinsley, Colin R

AU - Nassif, Xavier

AU - Kriz, Paula

AU - Ure, Roisin

AU - Gray, Steve J

AU - Derrick, Jeremy P

AU - Maiden, Martin C J

AU - Feavers, Ian M

PY - 2009/7/1

Y1 - 2009/7/1

N2 - The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.

AB - The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.

KW - Bacterial Proteins

KW - DNA Primers

KW - Humans

KW - Meningococcal Infections

KW - Neisseria gonorrhoeae

KW - Neisseria lactamica

KW - Neisseria meningitidis

KW - Receptors, Cell Surface

KW - Virulence

U2 - 10.1086/599377

DO - 10.1086/599377

M3 - Article

C2 - 19476432

SN - 0022-1899

VL - 200

SP - 94

EP - 98

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 1

ER -

Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence

Abstract

Keywords

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