Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence

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Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence. / Harrison, Odile B; Evans, Nicholas J; Blair, Jessica M; Grimes, Holly S; Tinsley, Colin R; Nassif, Xavier; Kriz, Paula; Ure, Roisin; Gray, Steve J; Derrick, Jeremy P; Maiden, Martin C J; Feavers, Ian M.

In: The Journal of Infectious Diseases, Vol. 200, No. 1, 01.07.2009, p. 94-8.

Research output: Contribution to journalArticlepeer-review

Harvard

Harrison, OB, Evans, NJ, Blair, JM, Grimes, HS, Tinsley, CR, Nassif, X, Kriz, P, Ure, R, Gray, SJ, Derrick, JP, Maiden, MCJ & Feavers, IM 2009, 'Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence', The Journal of Infectious Diseases, vol. 200, no. 1, pp. 94-8. https://doi.org/10.1086/599377

APA

Harrison, O. B., Evans, N. J., Blair, J. M., Grimes, H. S., Tinsley, C. R., Nassif, X., Kriz, P., Ure, R., Gray, S. J., Derrick, J. P., Maiden, M. C. J., & Feavers, I. M. (2009). Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence. The Journal of Infectious Diseases, 200(1), 94-8. https://doi.org/10.1086/599377

Vancouver

Author

Harrison, Odile B ; Evans, Nicholas J ; Blair, Jessica M ; Grimes, Holly S ; Tinsley, Colin R ; Nassif, Xavier ; Kriz, Paula ; Ure, Roisin ; Gray, Steve J ; Derrick, Jeremy P ; Maiden, Martin C J ; Feavers, Ian M. / Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence. In: The Journal of Infectious Diseases. 2009 ; Vol. 200, No. 1. pp. 94-8.

Bibtex

@article{8537199935b146ff81674d468c4066ac,
title = "Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence",
abstract = "The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a {"}pseudo hmbR{"} gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.",
keywords = "Bacterial Proteins, DNA Primers, Humans, Meningococcal Infections, Neisseria gonorrhoeae, Neisseria lactamica, Neisseria meningitidis, Receptors, Cell Surface, Virulence",
author = "Harrison, {Odile B} and Evans, {Nicholas J} and Blair, {Jessica M} and Grimes, {Holly S} and Tinsley, {Colin R} and Xavier Nassif and Paula Kriz and Roisin Ure and Gray, {Steve J} and Derrick, {Jeremy P} and Maiden, {Martin C J} and Feavers, {Ian M}",
year = "2009",
month = jul,
day = "1",
doi = "10.1086/599377",
language = "English",
volume = "200",
pages = "94--8",
journal = "The Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence

AU - Harrison, Odile B

AU - Evans, Nicholas J

AU - Blair, Jessica M

AU - Grimes, Holly S

AU - Tinsley, Colin R

AU - Nassif, Xavier

AU - Kriz, Paula

AU - Ure, Roisin

AU - Gray, Steve J

AU - Derrick, Jeremy P

AU - Maiden, Martin C J

AU - Feavers, Ian M

PY - 2009/7/1

Y1 - 2009/7/1

N2 - The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.

AB - The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.

KW - Bacterial Proteins

KW - DNA Primers

KW - Humans

KW - Meningococcal Infections

KW - Neisseria gonorrhoeae

KW - Neisseria lactamica

KW - Neisseria meningitidis

KW - Receptors, Cell Surface

KW - Virulence

U2 - 10.1086/599377

DO - 10.1086/599377

M3 - Article

C2 - 19476432

VL - 200

SP - 94

EP - 98

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -