Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

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Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. / Kingsley, RA; Msefula, CL; Thomson, NR; Kariuki, S; Holt, KE; Gordon, MA; Harris, D; Clarke, L; Whitehead, S; Sangal, V; Marsh, K; Achtman, M; Molyneux, ME; Cormican, M; Parkhill, J; MacLennan, Calman; Heyderman, RS; Dougan, G.

In: Genome Research, Vol. 19, No. 12, 01.12.2009, p. 2279-2287.

Research output: Contribution to journalArticle

Harvard

Kingsley, RA, Msefula, CL, Thomson, NR, Kariuki, S, Holt, KE, Gordon, MA, Harris, D, Clarke, L, Whitehead, S, Sangal, V, Marsh, K, Achtman, M, Molyneux, ME, Cormican, M, Parkhill, J, MacLennan, C, Heyderman, RS & Dougan, G 2009, 'Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype', Genome Research, vol. 19, no. 12, pp. 2279-2287. https://doi.org/10.1101/gr.091017.109

APA

Kingsley, RA., Msefula, CL., Thomson, NR., Kariuki, S., Holt, KE., Gordon, MA., Harris, D., Clarke, L., Whitehead, S., Sangal, V., Marsh, K., Achtman, M., Molyneux, ME., Cormican, M., Parkhill, J., MacLennan, C., Heyderman, RS., & Dougan, G. (2009). Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. Genome Research, 19(12), 2279-2287. https://doi.org/10.1101/gr.091017.109

Vancouver

Author

Kingsley, RA ; Msefula, CL ; Thomson, NR ; Kariuki, S ; Holt, KE ; Gordon, MA ; Harris, D ; Clarke, L ; Whitehead, S ; Sangal, V ; Marsh, K ; Achtman, M ; Molyneux, ME ; Cormican, M ; Parkhill, J ; MacLennan, Calman ; Heyderman, RS ; Dougan, G. / Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. In: Genome Research. 2009 ; Vol. 19, No. 12. pp. 2279-2287.

Bibtex

@article{bc38eb93922a4801a584152d548fa9a3,
title = "Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype",
abstract = "Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan Africa. Salmonella enterica serovar Typhimurium isolates are responsible for a significant proportion of the reported invasive NTS in this region. Multilocus sequence analysis of invasive S. Typhimurium from Malawi and Kenya identified a dominant type, designated ST313, which currently is rarely reported outside of Africa. Whole-genome sequencing of a multiple drug resistant (MDR) ST313 NTS isolate, D23580, identified a distinct prophage repertoire and a composite genetic element encoding MDR genes located on a virulence-associated plasmid. Further, there was evidence of genome degradation, including pseudogene formation and chromosomal deletions, when compared with other S. Typhimurium genome sequences. Some of this genome degradation involved genes previously implicated in virulence of S. Typhimurium or genes for which the orthologs in S. Typhi are either pseudogenes or are absent. Genome analysis of other epidemic ST313 isolates from Malawi and Kenya provided evidence for microevolution and clonal replacement in the field.",
author = "RA Kingsley and CL Msefula and NR Thomson and S Kariuki and KE Holt and MA Gordon and D Harris and L Clarke and S Whitehead and V Sangal and K Marsh and M Achtman and ME Molyneux and M Cormican and J Parkhill and Calman MacLennan and RS Heyderman and G Dougan",
year = "2009",
month = dec,
day = "1",
doi = "10.1101/gr.091017.109",
language = "English",
volume = "19",
pages = "2279--2287",
journal = "Genome Research",
issn = "1088-9051",
publisher = "Cold Spring Harbor Laboratory Press",
number = "12",

}

RIS

TY - JOUR

T1 - Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

AU - Kingsley, RA

AU - Msefula, CL

AU - Thomson, NR

AU - Kariuki, S

AU - Holt, KE

AU - Gordon, MA

AU - Harris, D

AU - Clarke, L

AU - Whitehead, S

AU - Sangal, V

AU - Marsh, K

AU - Achtman, M

AU - Molyneux, ME

AU - Cormican, M

AU - Parkhill, J

AU - MacLennan, Calman

AU - Heyderman, RS

AU - Dougan, G

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan Africa. Salmonella enterica serovar Typhimurium isolates are responsible for a significant proportion of the reported invasive NTS in this region. Multilocus sequence analysis of invasive S. Typhimurium from Malawi and Kenya identified a dominant type, designated ST313, which currently is rarely reported outside of Africa. Whole-genome sequencing of a multiple drug resistant (MDR) ST313 NTS isolate, D23580, identified a distinct prophage repertoire and a composite genetic element encoding MDR genes located on a virulence-associated plasmid. Further, there was evidence of genome degradation, including pseudogene formation and chromosomal deletions, when compared with other S. Typhimurium genome sequences. Some of this genome degradation involved genes previously implicated in virulence of S. Typhimurium or genes for which the orthologs in S. Typhi are either pseudogenes or are absent. Genome analysis of other epidemic ST313 isolates from Malawi and Kenya provided evidence for microevolution and clonal replacement in the field.

AB - Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan Africa. Salmonella enterica serovar Typhimurium isolates are responsible for a significant proportion of the reported invasive NTS in this region. Multilocus sequence analysis of invasive S. Typhimurium from Malawi and Kenya identified a dominant type, designated ST313, which currently is rarely reported outside of Africa. Whole-genome sequencing of a multiple drug resistant (MDR) ST313 NTS isolate, D23580, identified a distinct prophage repertoire and a composite genetic element encoding MDR genes located on a virulence-associated plasmid. Further, there was evidence of genome degradation, including pseudogene formation and chromosomal deletions, when compared with other S. Typhimurium genome sequences. Some of this genome degradation involved genes previously implicated in virulence of S. Typhimurium or genes for which the orthologs in S. Typhi are either pseudogenes or are absent. Genome analysis of other epidemic ST313 isolates from Malawi and Kenya provided evidence for microevolution and clonal replacement in the field.

U2 - 10.1101/gr.091017.109

DO - 10.1101/gr.091017.109

M3 - Article

C2 - 19901036

VL - 19

SP - 2279

EP - 2287

JO - Genome Research

JF - Genome Research

SN - 1088-9051

IS - 12

ER -