Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers

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Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers. / Insua, Ignacio; Liamas, Evangelos; Zhang, Zhenyu; Peacock, Anna F. A.; Krachler, Anne Marie; Fernandez-trillo, Francisco.

In: Polymer Chemistry, Vol. 2016, No. 15, 16.06.2016, p. 2684-2690.

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@article{5446b608f4214f9d9a36c7c5eab99242,
title = "Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers",
abstract = "Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa's elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimise particle size and charge, and their stability under physiological conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance.",
author = "Ignacio Insua and Evangelos Liamas and Zhenyu Zhang and Peacock, {Anna F. A.} and Krachler, {Anne Marie} and Francisco Fernandez-trillo",
year = "2016",
month = jun,
day = "16",
doi = "10.1039/C6PY00146G",
language = "English",
volume = "2016",
pages = "2684--2690",
journal = "Polymer Chemistry",
issn = "1759-9954",
publisher = "Royal Society of Chemistry",
number = "15",

}

RIS

TY - JOUR

T1 - Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers

AU - Insua, Ignacio

AU - Liamas, Evangelos

AU - Zhang, Zhenyu

AU - Peacock, Anna F. A.

AU - Krachler, Anne Marie

AU - Fernandez-trillo, Francisco

PY - 2016/6/16

Y1 - 2016/6/16

N2 - Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa's elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimise particle size and charge, and their stability under physiological conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance.

AB - Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa's elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimise particle size and charge, and their stability under physiological conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance.

U2 - 10.1039/C6PY00146G

DO - 10.1039/C6PY00146G

M3 - Article

VL - 2016

SP - 2684

EP - 2690

JO - Polymer Chemistry

JF - Polymer Chemistry

SN - 1759-9954

IS - 15

ER -