Environmental dimensions of the protein corona

Research output: Contribution to journalReview articlepeer-review

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Environmental dimensions of the protein corona. / Wheeler, Korin E.; Chetwynd, Andrew J.; Fahy, Kira M.; Hong, Brian S.; Tochihuitl, Jose A.; Foster, Lilah A.; Lynch, Iseult.

In: Nature Nanotechnology, Vol. 16, No. 6, 11.06.2021, p. 617-629.

Research output: Contribution to journalReview articlepeer-review

Harvard

Wheeler, KE, Chetwynd, AJ, Fahy, KM, Hong, BS, Tochihuitl, JA, Foster, LA & Lynch, I 2021, 'Environmental dimensions of the protein corona', Nature Nanotechnology, vol. 16, no. 6, pp. 617-629. https://doi.org/10.1038/s41565-021-00924-1

APA

Wheeler, K. E., Chetwynd, A. J., Fahy, K. M., Hong, B. S., Tochihuitl, J. A., Foster, L. A., & Lynch, I. (2021). Environmental dimensions of the protein corona. Nature Nanotechnology, 16(6), 617-629. https://doi.org/10.1038/s41565-021-00924-1

Vancouver

Wheeler KE, Chetwynd AJ, Fahy KM, Hong BS, Tochihuitl JA, Foster LA et al. Environmental dimensions of the protein corona. Nature Nanotechnology. 2021 Jun 11;16(6):617-629. https://doi.org/10.1038/s41565-021-00924-1

Author

Wheeler, Korin E. ; Chetwynd, Andrew J. ; Fahy, Kira M. ; Hong, Brian S. ; Tochihuitl, Jose A. ; Foster, Lilah A. ; Lynch, Iseult. / Environmental dimensions of the protein corona. In: Nature Nanotechnology. 2021 ; Vol. 16, No. 6. pp. 617-629.

Bibtex

@article{3abc20e1625247c8b24bdd79271f2028,
title = "Environmental dimensions of the protein corona",
abstract = "The adsorption of biomolecules to the surface of engineered nanomaterials, known as corona formation, defines their biological identity by altering their surface properties and transforming the physical, chemical and biological characteristics of the particles. In the first decade since the term protein corona was coined, studies have focused primarily on biomedical applications and human toxicity. The relevance of the environmental dimensions of the protein corona is still emerging. Often referred to as the eco-corona, a biomolecular coating forms upon nanomaterials as they enter the environment and may include proteins, as well as a diverse array of other biomolecules such as metabolites from cellular activity and/or natural organic matter. Proteins remain central in studies of eco-coronas because of the ease of monitoring and structurally characterizing proteins, as well as their crucial role in receptor engagement and signalling. The proteins within the eco-corona are optimal targets to establish the biophysicochemical principles of corona formation and transformation, as well as downstream impacts on nanomaterial uptake, distribution and impacts on the environment. Moreover, proteins appear to impart a biological identity, leading to cellular or organismal recognition of nanomaterials, a unique characteristic compared with natural organic matter. We contrast insights into protein corona formation from clinical samples with those in environmentally relevant systems. Principles specific to the environment are also explored to gain insights into the dynamics of interaction with or replacement by other biomolecules, including changes during trophic transfer and ecotoxicity. With many challenges remaining, we also highlight key opportunities for method development and impactful systems on which to focus the next phase of eco-corona studies. By interrogating these environmental dimensions of the protein corona, we offer a perspective on how mechanistic insights into protein coronas in the environment can lead to more sustainable, environmentally safe nanomaterials, as well as enhancing the efficacy of nanomaterials used in remediation and in the agri-food sector.",
author = "Wheeler, {Korin E.} and Chetwynd, {Andrew J.} and Fahy, {Kira M.} and Hong, {Brian S.} and Tochihuitl, {Jose A.} and Foster, {Lilah A.} and Iseult Lynch",
note = "Funding Information: K.E.W., K.M.F. and B.S.H. acknowledge support from the Henry Dreyfus Teacher-Scholar Awards Program, the Jean Dreyfus Lectureship for Undergraduate Institutions and the DeNardo Scholars Program, respectively. A.J.C. and I.L. acknowledge funding from the European Union Horizon 2020 project ACEnano (grant agreement no. 720952) and H2020 research infrastructure project NanoCommons (grant agreement no. 731032) and the Natural Environment Research Council (NE/N006569/1). Publisher Copyright: {\textcopyright} 2021, Springer Nature Limited.",
year = "2021",
month = jun,
day = "11",
doi = "10.1038/s41565-021-00924-1",
language = "English",
volume = "16",
pages = "617--629",
journal = "Nature Nanotechnology",
issn = "1748-3387",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Environmental dimensions of the protein corona

AU - Wheeler, Korin E.

AU - Chetwynd, Andrew J.

AU - Fahy, Kira M.

AU - Hong, Brian S.

AU - Tochihuitl, Jose A.

AU - Foster, Lilah A.

AU - Lynch, Iseult

N1 - Funding Information: K.E.W., K.M.F. and B.S.H. acknowledge support from the Henry Dreyfus Teacher-Scholar Awards Program, the Jean Dreyfus Lectureship for Undergraduate Institutions and the DeNardo Scholars Program, respectively. A.J.C. and I.L. acknowledge funding from the European Union Horizon 2020 project ACEnano (grant agreement no. 720952) and H2020 research infrastructure project NanoCommons (grant agreement no. 731032) and the Natural Environment Research Council (NE/N006569/1). Publisher Copyright: © 2021, Springer Nature Limited.

PY - 2021/6/11

Y1 - 2021/6/11

N2 - The adsorption of biomolecules to the surface of engineered nanomaterials, known as corona formation, defines their biological identity by altering their surface properties and transforming the physical, chemical and biological characteristics of the particles. In the first decade since the term protein corona was coined, studies have focused primarily on biomedical applications and human toxicity. The relevance of the environmental dimensions of the protein corona is still emerging. Often referred to as the eco-corona, a biomolecular coating forms upon nanomaterials as they enter the environment and may include proteins, as well as a diverse array of other biomolecules such as metabolites from cellular activity and/or natural organic matter. Proteins remain central in studies of eco-coronas because of the ease of monitoring and structurally characterizing proteins, as well as their crucial role in receptor engagement and signalling. The proteins within the eco-corona are optimal targets to establish the biophysicochemical principles of corona formation and transformation, as well as downstream impacts on nanomaterial uptake, distribution and impacts on the environment. Moreover, proteins appear to impart a biological identity, leading to cellular or organismal recognition of nanomaterials, a unique characteristic compared with natural organic matter. We contrast insights into protein corona formation from clinical samples with those in environmentally relevant systems. Principles specific to the environment are also explored to gain insights into the dynamics of interaction with or replacement by other biomolecules, including changes during trophic transfer and ecotoxicity. With many challenges remaining, we also highlight key opportunities for method development and impactful systems on which to focus the next phase of eco-corona studies. By interrogating these environmental dimensions of the protein corona, we offer a perspective on how mechanistic insights into protein coronas in the environment can lead to more sustainable, environmentally safe nanomaterials, as well as enhancing the efficacy of nanomaterials used in remediation and in the agri-food sector.

AB - The adsorption of biomolecules to the surface of engineered nanomaterials, known as corona formation, defines their biological identity by altering their surface properties and transforming the physical, chemical and biological characteristics of the particles. In the first decade since the term protein corona was coined, studies have focused primarily on biomedical applications and human toxicity. The relevance of the environmental dimensions of the protein corona is still emerging. Often referred to as the eco-corona, a biomolecular coating forms upon nanomaterials as they enter the environment and may include proteins, as well as a diverse array of other biomolecules such as metabolites from cellular activity and/or natural organic matter. Proteins remain central in studies of eco-coronas because of the ease of monitoring and structurally characterizing proteins, as well as their crucial role in receptor engagement and signalling. The proteins within the eco-corona are optimal targets to establish the biophysicochemical principles of corona formation and transformation, as well as downstream impacts on nanomaterial uptake, distribution and impacts on the environment. Moreover, proteins appear to impart a biological identity, leading to cellular or organismal recognition of nanomaterials, a unique characteristic compared with natural organic matter. We contrast insights into protein corona formation from clinical samples with those in environmentally relevant systems. Principles specific to the environment are also explored to gain insights into the dynamics of interaction with or replacement by other biomolecules, including changes during trophic transfer and ecotoxicity. With many challenges remaining, we also highlight key opportunities for method development and impactful systems on which to focus the next phase of eco-corona studies. By interrogating these environmental dimensions of the protein corona, we offer a perspective on how mechanistic insights into protein coronas in the environment can lead to more sustainable, environmentally safe nanomaterials, as well as enhancing the efficacy of nanomaterials used in remediation and in the agri-food sector.

UR - http://www.scopus.com/inward/record.url?scp=85107635808&partnerID=8YFLogxK

U2 - 10.1038/s41565-021-00924-1

DO - 10.1038/s41565-021-00924-1

M3 - Review article

C2 - 34117462

AN - SCOPUS:85107635808

VL - 16

SP - 617

EP - 629

JO - Nature Nanotechnology

JF - Nature Nanotechnology

SN - 1748-3387

IS - 6

ER -