TY - JOUR
T1 - ENIGMA and global neuroscience
T2 - A decade of large-scale studies of the brain in health and disease across more than 40 countries
AU - for the ENIGMA Consortium
AU - Thompson, Paul M.
AU - Jahanshad, Neda
AU - Ching, Christopher R.K.
AU - Salminen, Lauren E.
AU - Thomopoulos, Sophia I.
AU - Bright, Joanna
AU - Baune, Bernhard T.
AU - Bertolín, Sara
AU - Bralten, Janita
AU - Bruin, Willem B.
AU - Bülow, Robin
AU - Chen, Jian
AU - Chye, Yann
AU - Dannlowski, Udo
AU - de Kovel, Carolien G.F.
AU - Donohoe, Gary
AU - Eyler, Lisa T.
AU - Faraone, Stephen V.
AU - Favre, Pauline
AU - Filippi, Courtney A.
AU - Frodl, Thomas
AU - Garijo, Daniel
AU - Gil, Yolanda
AU - Grabe, Hans J.
AU - Grasby, Katrina L.
AU - Hajek, Tomas
AU - Han, Laura K.M.
AU - Hatton, Sean N.
AU - Hilbert, Kevin
AU - Ho, Tiffany C.
AU - Holleran, Laurena
AU - Homuth, Georg
AU - Hosten, Norbert
AU - Houenou, Josselin
AU - Ivanov, Iliyan
AU - Jia, Tianye
AU - Kelly, Sinead
AU - Klein, Marieke
AU - Kwon, Jun Soo
AU - Laansma, Max A.
AU - Leerssen, Jeanne
AU - Lueken, Ulrike
AU - Nunes, Abraham
AU - Neill, Joseph O’
AU - Opel, Nils
AU - Piras, Fabrizio
AU - Piras, Federica
AU - Postema, Merel C.
AU - Pozzi, Elena
AU - Shatokhina, Natalia
AU - Soriano-Mas, Carles
AU - Spalletta, Gianfranco
AU - Sun, Daqiang
AU - Teumer, Alexander
AU - Tilot, Amanda
AU - Tozzi, Leonardo
AU - van der Merwe, Celia
AU - Van Someren, Eus
AU - van Wingen, Guido
AU - Völzke, Henry
AU - Walton, Esther
AU - Wang, Lei
AU - Winkler, Anderson
AU - Wittfeld, Katharina
AU - Wright, Margaret J
AU - Yun, Je-Yeon
AU - Zhang, Guohao
AU - Zhang-James, Yanli
AU - Adhikari, Bhim
AU - Agartz, Ingrid
AU - Aghajani, Moji
AU - Aleman, André
AU - Althof, Robert R
AU - Altmann, Andre
AU - Andreassen, Ole
AU - Baron, David
AU - Bartnik-Olson, Brenda
AU - Bas-Hoogendam, Janna Marie
AU - Baskin-Sommers, Arielle R
AU - Bearden, Carrie E.
AU - Berner, Laura
AU - Boedhoe, Premika
AU - Brouwer, Rachel
AU - Buitelaar, Jan K
AU - Caeyenberghs, Karen
AU - Cecil, Charlotte A M
AU - Cohen, Ronald
AU - Cole, James
AU - Conrod, Patricia
AU - De Brito, Stephane A.
AU - Zwarte, Sonja
AU - Denis, Emily
AU - Desriviere, Sylvane
AU - Dima, Danai
AU - Ehrlich, Stefan
AU - Esopenko, Carrie
AU - Fairchild, Graeme
AU - Fisher, Simon E
AU - Fouche, Jean-Paul
AU - Franks, Clyde
AU - Frangou, Sophia
AU - Franke, Barbara
AU - Garavan, Hugh P
AU - Glahn, David C.
AU - Groenewold, Nynke A.
AU - Gurholt, Tiril P.
AU - Gutman, Boris A.
AU - Hahn, Tim
AU - Harding, Ian H.
AU - Hernaus, Dennis
AU - Hibar, Derrek P.
AU - Hillary, Frank G.
AU - Hoogman, Martine
AU - Hulshoff Pol, Hilleke E.
AU - Jalbrzikowski, Maria
AU - Karkashadze, George A.
AU - Klapwijk, Eduard T.
AU - Knickmeyer, Rebecca C.
AU - Kochunov, Peter
AU - Koerte, Inga K.q
AU - Kong, Xiang-Zhen
AU - Liew, Sook-Lei
AU - Lin, Alexander P.
AU - Logue, Mark W.
AU - Luders, Eileen
AU - Macciardi, Fabio
AU - Mackey, Scott
AU - Mayer, Andrew R.
AU - McDonald, Carrie
AU - McMahon, Agnes B.
AU - Medland, Sarah E.
AU - Modinos, Gemma
AU - Morey, Rajendra A.
AU - Mueller, Sven C.
AU - Mukherjee, Pratik
AU - Namazova-Baranova, Leyla
AU - Nir, Talia M.
AU - Olsen, Alexander
AU - Paschou, Peristera
AU - Pine, Daniel S.
AU - Pizzagalli, Fabrizio
AU - Rentería, Miguel E.
AU - Rohrer, Jonathan D.
AU - Sämann, Philipp G.
AU - Schmaal, Lianne
PY - 2020/3/20
Y1 - 2020/3/20
N2 - This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of “big data” (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA’s activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.
AB - This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of “big data” (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA’s activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.
UR - http://www.scopus.com/inward/record.url?scp=85082148270&partnerID=8YFLogxK
U2 - 10.1038/s41398-020-0705-1
DO - 10.1038/s41398-020-0705-1
M3 - Review article
C2 - 32198361
AN - SCOPUS:85082148270
SN - 2158-3188
VL - 10
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 100
ER -