Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
- University of Warwick
Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.
|Journal||Journal of Medicinal Chemistry|
|Early online date||23 Sep 2015|
|Publication status||Published - 8 Oct 2015|