Abstract
Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.
Original language | English |
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Pages (from-to) | 7874-7880 |
Journal | Journal of Medicinal Chemistry |
Volume | 58 |
Issue number | 19 |
Early online date | 23 Sept 2015 |
DOIs | |
Publication status | Published - 8 Oct 2015 |