Abstract
Adrenergic agonists provoke a marked increase in labelling of phosphatidylinositol in fragments of rat parotid gland. Adrenaline and phenylephrine (an adrenergic α agonist) are effective stimulants, but isoprenaline (an adrenergic β agonist) is relatively ineffective. The response evoked by phenylephrine or adrenaline is prevented by prior incubation of the tissue with phenoxybenzamine (an α receptor blocking agent), but not by prior incubation with pindolol (a β receptor blocking agent). Adrenergic stimulation of phosphatidylinositol metabolism in parotid gland is therefore mediated through α receptors, in common with the adrenaline induced K+ efflux. It is not linked to enzyme secretion, which is triggered by stimulation of β receptors. It is suggested that the stimulation of phospholipid metabolism that occurs in several other tissues in the presence of adrenaline or noradrenaline may also involve α receptors.
Original language | English |
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Pages (from-to) | 47-52 |
Number of pages | 6 |
Journal | Biochemical Journal |
Volume | 138 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 1974 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology