Enhanced phosphatidylinositol labelling in rat parotid fragments exposed to α adrenergic stimulation

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Adrenergic agonists provoke a marked increase in labelling of phosphatidylinositol in fragments of rat parotid gland. Adrenaline and phenylephrine (an adrenergic α agonist) are effective stimulants, but isoprenaline (an adrenergic β agonist) is relatively ineffective. The response evoked by phenylephrine or adrenaline is prevented by prior incubation of the tissue with phenoxybenzamine (an α receptor blocking agent), but not by prior incubation with pindolol (a β receptor blocking agent). Adrenergic stimulation of phosphatidylinositol metabolism in parotid gland is therefore mediated through α receptors, in common with the adrenaline induced K+ efflux. It is not linked to enzyme secretion, which is triggered by stimulation of β receptors. It is suggested that the stimulation of phospholipid metabolism that occurs in several other tissues in the presence of adrenaline or noradrenaline may also involve α receptors.


Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalBiochemical Journal
Issue number1
Publication statusPublished - 1 Jan 1974