Enhanced phosphatidylinositol labelling in rat parotid fragments exposed to α adrenergic stimulation
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Adrenergic agonists provoke a marked increase in labelling of phosphatidylinositol in fragments of rat parotid gland. Adrenaline and phenylephrine (an adrenergic α agonist) are effective stimulants, but isoprenaline (an adrenergic β agonist) is relatively ineffective. The response evoked by phenylephrine or adrenaline is prevented by prior incubation of the tissue with phenoxybenzamine (an α receptor blocking agent), but not by prior incubation with pindolol (a β receptor blocking agent). Adrenergic stimulation of phosphatidylinositol metabolism in parotid gland is therefore mediated through α receptors, in common with the adrenaline induced K+ efflux. It is not linked to enzyme secretion, which is triggered by stimulation of β receptors. It is suggested that the stimulation of phospholipid metabolism that occurs in several other tissues in the presence of adrenaline or noradrenaline may also involve α receptors.
|Number of pages||6|
|Publication status||Published - 1 Jan 1974|