Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

Thine Hvid; Kamilla Winding; Anders Rinnov; Thomas Dejgaard; Carsten Thomsen; Peter Iversen; Klaus Brasso; Kari J Mikines; Gerrit van Hall; Birgitte Lindegaard; Thomas P J Solomon; Bente K Pedersen

doi:10.1530/ERC-12-0393

Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

Thine Hvid, Kamilla Winding, Anders Rinnov, Thomas Dejgaard, Carsten Thomsen, Peter Iversen, Klaus Brasso, Kari J Mikines, Gerrit van Hall, Birgitte Lindegaard, Thomas P J Solomon, Bente K Pedersen

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P<0.0001). The patients and controls demonstrated an increase in peripheral tissue insulin sensitivity of 14 and 11% respectively (P<0.05), with no effect on hepatic insulin sensitivity (P=0.32). Muscle protein content of GLUT4 (SLC2A4) and total AKT (AKT1) was also increased in response to the training (P<0.05 and P<0.01 respectively). Body weight (P<0.0001) and whole-body fat mass (FM) (P<0.01) were reduced, while lean body mass (P=0.99) was unchanged. Additionally, reductions were observed in abdominal (P<0.01), subcutaneous (P<0.05), and visceral (P<0.01) FM amounts. The concentrations of plasma markers of systemic inflammation were unchanged in response to the training. No group × time interactions were observed, except for thigh intermuscular adipose tissue (IMAT) (P=0.01), reflecting a significant reduction in the amount of IMAT in the controls (P<0.05) not observed in the patients (P=0.64). In response to endurance training, ADT-treated prostate cancer patients exhibited improved insulin sensitivity and body composition to a similar degree as eugonadal men.

Original language	English
Pages (from-to)	621-32
Number of pages	12
Journal	Endocrine-related cancer
Volume	20
Issue number	5
DOIs	https://doi.org/10.1530/ERC-12-0393
Publication status	Published - Oct 2013

Keywords

Aged
Antineoplastic Agents, Hormonal
Blood Glucose
Body Composition
Cholesterol, HDL
Exercise Therapy
Glucose Tolerance Test
Gonadotropin-Releasing Hormone
Goserelin
Humans
Insulin Resistance
Male
Middle Aged
Physical Endurance
Prostatic Neoplasms
Testosterone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1530/ERC-12-0393

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Hvid, T., Winding, K., Rinnov, A., Dejgaard, T., Thomsen, C., Iversen, P., Brasso, K., Mikines, K. J., van Hall, G., Lindegaard, B., Solomon, T. P. J., & Pedersen, B. K. (2013). Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy. Endocrine-related cancer, 20(5), 621-32. https://doi.org/10.1530/ERC-12-0393

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abstract = "Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P<0.0001). The patients and controls demonstrated an increase in peripheral tissue insulin sensitivity of 14 and 11% respectively (P<0.05), with no effect on hepatic insulin sensitivity (P=0.32). Muscle protein content of GLUT4 (SLC2A4) and total AKT (AKT1) was also increased in response to the training (P<0.05 and P<0.01 respectively). Body weight (P<0.0001) and whole-body fat mass (FM) (P<0.01) were reduced, while lean body mass (P=0.99) was unchanged. Additionally, reductions were observed in abdominal (P<0.01), subcutaneous (P<0.05), and visceral (P<0.01) FM amounts. The concentrations of plasma markers of systemic inflammation were unchanged in response to the training. No group × time interactions were observed, except for thigh intermuscular adipose tissue (IMAT) (P=0.01), reflecting a significant reduction in the amount of IMAT in the controls (P<0.05) not observed in the patients (P=0.64). In response to endurance training, ADT-treated prostate cancer patients exhibited improved insulin sensitivity and body composition to a similar degree as eugonadal men.",

keywords = "Aged, Antineoplastic Agents, Hormonal, Blood Glucose, Body Composition, Cholesterol, HDL, Exercise Therapy, Glucose Tolerance Test, Gonadotropin-Releasing Hormone, Goserelin, Humans, Insulin Resistance, Male, Middle Aged, Physical Endurance, Prostatic Neoplasms, Testosterone",

author = "Thine Hvid and Kamilla Winding and Anders Rinnov and Thomas Dejgaard and Carsten Thomsen and Peter Iversen and Klaus Brasso and Mikines, {Kari J} and {van Hall}, Gerrit and Birgitte Lindegaard and Solomon, {Thomas P J} and Pedersen, {Bente K}",

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doi = "10.1530/ERC-12-0393",

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Hvid, T, Winding, K, Rinnov, A, Dejgaard, T, Thomsen, C, Iversen, P, Brasso, K, Mikines, KJ, van Hall, G, Lindegaard, B, Solomon, TPJ & Pedersen, BK 2013, 'Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy', Endocrine-related cancer, vol. 20, no. 5, pp. 621-32. https://doi.org/10.1530/ERC-12-0393

TY - JOUR

T1 - Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

AU - Hvid, Thine

AU - Winding, Kamilla

AU - Rinnov, Anders

AU - Dejgaard, Thomas

AU - Thomsen, Carsten

AU - Iversen, Peter

AU - Brasso, Klaus

AU - Mikines, Kari J

AU - van Hall, Gerrit

AU - Lindegaard, Birgitte

AU - Solomon, Thomas P J

AU - Pedersen, Bente K

PY - 2013/10

Y1 - 2013/10

N2 - Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P<0.0001). The patients and controls demonstrated an increase in peripheral tissue insulin sensitivity of 14 and 11% respectively (P<0.05), with no effect on hepatic insulin sensitivity (P=0.32). Muscle protein content of GLUT4 (SLC2A4) and total AKT (AKT1) was also increased in response to the training (P<0.05 and P<0.01 respectively). Body weight (P<0.0001) and whole-body fat mass (FM) (P<0.01) were reduced, while lean body mass (P=0.99) was unchanged. Additionally, reductions were observed in abdominal (P<0.01), subcutaneous (P<0.05), and visceral (P<0.01) FM amounts. The concentrations of plasma markers of systemic inflammation were unchanged in response to the training. No group × time interactions were observed, except for thigh intermuscular adipose tissue (IMAT) (P=0.01), reflecting a significant reduction in the amount of IMAT in the controls (P<0.05) not observed in the patients (P=0.64). In response to endurance training, ADT-treated prostate cancer patients exhibited improved insulin sensitivity and body composition to a similar degree as eugonadal men.

AB - Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P<0.0001). The patients and controls demonstrated an increase in peripheral tissue insulin sensitivity of 14 and 11% respectively (P<0.05), with no effect on hepatic insulin sensitivity (P=0.32). Muscle protein content of GLUT4 (SLC2A4) and total AKT (AKT1) was also increased in response to the training (P<0.05 and P<0.01 respectively). Body weight (P<0.0001) and whole-body fat mass (FM) (P<0.01) were reduced, while lean body mass (P=0.99) was unchanged. Additionally, reductions were observed in abdominal (P<0.01), subcutaneous (P<0.05), and visceral (P<0.01) FM amounts. The concentrations of plasma markers of systemic inflammation were unchanged in response to the training. No group × time interactions were observed, except for thigh intermuscular adipose tissue (IMAT) (P=0.01), reflecting a significant reduction in the amount of IMAT in the controls (P<0.05) not observed in the patients (P=0.64). In response to endurance training, ADT-treated prostate cancer patients exhibited improved insulin sensitivity and body composition to a similar degree as eugonadal men.

KW - Aged

KW - Antineoplastic Agents, Hormonal

KW - Blood Glucose

KW - Body Composition

KW - Cholesterol, HDL

KW - Exercise Therapy

KW - Glucose Tolerance Test

KW - Gonadotropin-Releasing Hormone

KW - Goserelin

KW - Humans

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Physical Endurance

KW - Prostatic Neoplasms

KW - Testosterone

U2 - 10.1530/ERC-12-0393

DO - 10.1530/ERC-12-0393

M3 - Article

C2 - 23744766

SN - 1351-0088

VL - 20

SP - 621

EP - 632

JO - Endocrine-related cancer

JF - Endocrine-related cancer

IS - 5

ER -

Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

Abstract

Keywords

UN SDGs

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