Endothelial function and its assessment

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Endothelial function and its assessment. / Felmeden, DC; Lip, Gregory.

In: Journal of Human Hypertension, Vol. 14, No. 11, 01.11.2005, p. 1319-36.

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Felmeden, DC ; Lip, Gregory. / Endothelial function and its assessment. In: Journal of Human Hypertension. 2005 ; Vol. 14, No. 11. pp. 1319-36.

Bibtex

@article{ff8d0457fa1b4b47b7e2cb31e1605a92,
title = "Endothelial function and its assessment",
abstract = "Endothelial dysfunction is a characteristic aspect of most of the conditions associated with atherosclerosis and is commonly found as an early feature in atherothrombotic vascular disease. An appreciation of the underlying mechanisms of endothelial function, as well as dysfunction, is essential as this has critical influence on the different methods in the assessment of endothelial function and effects of various treatments on its quantification. Furthermore, endothelial dysfunction is recognised as a type of 'target organ damage' in common cardiovascular conditions (e.g., hypertension) and the area is of increasing interest for new drug development, as therapies that modulate the endothelium will have added advantages; thus, for the development of new/experimental drugs, an awareness of ways to assess the endothelium is necessary. In this review, an overview of different methods including biochemical markers, and invasive and non-invasive tools, to determine endothelial function is presented as well as their clinical relevance. Furthermore, the effects of various treatments on endothelial dysfunction and their underlying mechanisms are elucidated.",
keywords = "cilatation, flow mediated, endothelial function, assessment",
author = "DC Felmeden and Gregory Lip",
year = "2005",
month = nov,
day = "1",
doi = "10.1517/13543784.14.11.1319",
language = "English",
volume = "14",
pages = "1319--36",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Endothelial function and its assessment

AU - Felmeden, DC

AU - Lip, Gregory

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Endothelial dysfunction is a characteristic aspect of most of the conditions associated with atherosclerosis and is commonly found as an early feature in atherothrombotic vascular disease. An appreciation of the underlying mechanisms of endothelial function, as well as dysfunction, is essential as this has critical influence on the different methods in the assessment of endothelial function and effects of various treatments on its quantification. Furthermore, endothelial dysfunction is recognised as a type of 'target organ damage' in common cardiovascular conditions (e.g., hypertension) and the area is of increasing interest for new drug development, as therapies that modulate the endothelium will have added advantages; thus, for the development of new/experimental drugs, an awareness of ways to assess the endothelium is necessary. In this review, an overview of different methods including biochemical markers, and invasive and non-invasive tools, to determine endothelial function is presented as well as their clinical relevance. Furthermore, the effects of various treatments on endothelial dysfunction and their underlying mechanisms are elucidated.

AB - Endothelial dysfunction is a characteristic aspect of most of the conditions associated with atherosclerosis and is commonly found as an early feature in atherothrombotic vascular disease. An appreciation of the underlying mechanisms of endothelial function, as well as dysfunction, is essential as this has critical influence on the different methods in the assessment of endothelial function and effects of various treatments on its quantification. Furthermore, endothelial dysfunction is recognised as a type of 'target organ damage' in common cardiovascular conditions (e.g., hypertension) and the area is of increasing interest for new drug development, as therapies that modulate the endothelium will have added advantages; thus, for the development of new/experimental drugs, an awareness of ways to assess the endothelium is necessary. In this review, an overview of different methods including biochemical markers, and invasive and non-invasive tools, to determine endothelial function is presented as well as their clinical relevance. Furthermore, the effects of various treatments on endothelial dysfunction and their underlying mechanisms are elucidated.

KW - cilatation

KW - flow mediated

KW - endothelial function

KW - assessment

U2 - 10.1517/13543784.14.11.1319

DO - 10.1517/13543784.14.11.1319

M3 - Article

C2 - 16255673

VL - 14

SP - 1319

EP - 1336

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 11

ER -