Endothelial damage and angiogenesis in hypertensive patients: relationship to cardiovascular risk factors and risk factor management

Research output: Contribution to journalArticle

Authors

  • Dirk Felmeden
  • Charles Spencer
  • Funmilayo Belgore
  • Andrew Blann

Abstract

BACKGROUND: Hypertensive patients are at particular risk of cardiovascular complications, possibly related to endothelial damage or dysfunction, or to abnormal angiogenesis. These pathophysiologic processes are assessable by measurement of plasma levels of von Willebrand factor (vWf), and by vascular endothelial growth factor (VEGF) and its soluble receptor (sFlt-1). We hypothesized that these markers would correlate with the Framingham cardiovascular risk score and would be responsive to treatment. METHODS: We measured these markers by enzyme-linked immunosorbent assay in 286 patients with hypertension (239 men; mean age 63 years; mean systolic blood pressure [BP]/diastolic BP 162/89 mm Hg) and additional risk factors, and related them to the patient's cardiovascular disease (CVD) and cerebrovascular accident (CVA) risk, using the Framingham equation. Patients were compared with 60 healthy normotensive controls. In 248 patients, the effects of 6 months of intensified cardiovascular risk factor management, including BP and (where appropriate) lipid-lowering treatment, were investigated. RESULTS: Plasma VEGF and vWf levels were higher, but sFlt-1 levels lower (all P

Details

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalAmerican Journal of Hypertension
Volume16
Issue number1
Publication statusPublished - 1 Jan 2003