Endothelial cells: source, barrier, and target of defensive mediators

Research output: Contribution to journalReview articlepeer-review

Standard

Endothelial cells : source, barrier, and target of defensive mediators. / Roumenina, Lubka T.; Rayes, Julie; Frimat, Marie; Fremeaux-Bacchi, Veronique.

In: Immunological Reviews, Vol. 274, No. 1, 01.11.2016, p. 307-329.

Research output: Contribution to journalReview articlepeer-review

Harvard

APA

Vancouver

Author

Roumenina, Lubka T. ; Rayes, Julie ; Frimat, Marie ; Fremeaux-Bacchi, Veronique. / Endothelial cells : source, barrier, and target of defensive mediators. In: Immunological Reviews. 2016 ; Vol. 274, No. 1. pp. 307-329.

Bibtex

@article{771135b5762e46d2afa58d779131cc3c,
title = "Endothelial cells: source, barrier, and target of defensive mediators",
abstract = "Endothelium is strategically located at the interface between blood and interstitial tissues, placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are in a dynamic equilibrium with their environment and constitute concomitantly a source, a barrier, and a target of defensive mediators. This review will discuss the recent advances in our understanding of the complex crosstalk between the endothelium, the complement system and the hemostasis in health and in disease. The first part will provide a general introduction on endothelial cells heterogeneity and on the physiologic role of the complement and hemostatic systems. The second part will analyze the interplay between complement, hemostasis and endothelial cells in physiological conditions and their alterations in diseases. Particular focus will be made on the prototypes of thrombotic microangiopathic disorders, resulting from complement or hemostasis dysregulation-mediated endothelial damage: atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Novel aspects of the pathophysiology of the thrombotic microangiopathies will be discussed.",
keywords = "atypical hemolytic uremic syndrome, complement system, endothelial cells, hemolysis, hemostasis, thrombosis",
author = "Roumenina, {Lubka T.} and Julie Rayes and Marie Frimat and Veronique Fremeaux-Bacchi",
year = "2016",
month = nov,
day = "1",
doi = "10.1111/imr.12479",
language = "English",
volume = "274",
pages = "307--329",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Endothelial cells

T2 - source, barrier, and target of defensive mediators

AU - Roumenina, Lubka T.

AU - Rayes, Julie

AU - Frimat, Marie

AU - Fremeaux-Bacchi, Veronique

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Endothelium is strategically located at the interface between blood and interstitial tissues, placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are in a dynamic equilibrium with their environment and constitute concomitantly a source, a barrier, and a target of defensive mediators. This review will discuss the recent advances in our understanding of the complex crosstalk between the endothelium, the complement system and the hemostasis in health and in disease. The first part will provide a general introduction on endothelial cells heterogeneity and on the physiologic role of the complement and hemostatic systems. The second part will analyze the interplay between complement, hemostasis and endothelial cells in physiological conditions and their alterations in diseases. Particular focus will be made on the prototypes of thrombotic microangiopathic disorders, resulting from complement or hemostasis dysregulation-mediated endothelial damage: atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Novel aspects of the pathophysiology of the thrombotic microangiopathies will be discussed.

AB - Endothelium is strategically located at the interface between blood and interstitial tissues, placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are in a dynamic equilibrium with their environment and constitute concomitantly a source, a barrier, and a target of defensive mediators. This review will discuss the recent advances in our understanding of the complex crosstalk between the endothelium, the complement system and the hemostasis in health and in disease. The first part will provide a general introduction on endothelial cells heterogeneity and on the physiologic role of the complement and hemostatic systems. The second part will analyze the interplay between complement, hemostasis and endothelial cells in physiological conditions and their alterations in diseases. Particular focus will be made on the prototypes of thrombotic microangiopathic disorders, resulting from complement or hemostasis dysregulation-mediated endothelial damage: atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Novel aspects of the pathophysiology of the thrombotic microangiopathies will be discussed.

KW - atypical hemolytic uremic syndrome

KW - complement system

KW - endothelial cells

KW - hemolysis

KW - hemostasis

KW - thrombosis

UR - http://www.scopus.com/inward/record.url?scp=84992470016&partnerID=8YFLogxK

U2 - 10.1111/imr.12479

DO - 10.1111/imr.12479

M3 - Review article

C2 - 27782324

AN - SCOPUS:84992470016

VL - 274

SP - 307

EP - 329

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -