Endothelial cells: source, barrier, and target of defensive mediators

Research output: Contribution to journalReview articlepeer-review

Authors

  • Lubka T. Roumenina
  • Julie Rayes
  • Marie Frimat
  • Veronique Fremeaux-Bacchi

Colleges, School and Institutes

External organisations

  • INSERM
  • CHU Lille
  • Hôpital Européen Georges Pompidou

Abstract

Endothelium is strategically located at the interface between blood and interstitial tissues, placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are in a dynamic equilibrium with their environment and constitute concomitantly a source, a barrier, and a target of defensive mediators. This review will discuss the recent advances in our understanding of the complex crosstalk between the endothelium, the complement system and the hemostasis in health and in disease. The first part will provide a general introduction on endothelial cells heterogeneity and on the physiologic role of the complement and hemostatic systems. The second part will analyze the interplay between complement, hemostasis and endothelial cells in physiological conditions and their alterations in diseases. Particular focus will be made on the prototypes of thrombotic microangiopathic disorders, resulting from complement or hemostasis dysregulation-mediated endothelial damage: atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Novel aspects of the pathophysiology of the thrombotic microangiopathies will be discussed.

Details

Original languageEnglish
Pages (from-to)307-329
Number of pages23
JournalImmunological Reviews
Volume274
Issue number1
Publication statusPublished - 1 Nov 2016

Keywords

  • atypical hemolytic uremic syndrome, complement system, endothelial cells, hemolysis, hemostasis, thrombosis

ASJC Scopus subject areas