Endothelial cell and T-cell crosstalk: targeting metabolism as a therapeutic approach in chronic inflammation

Research output: Contribution to journalReview article

Authors

  • Hagar Elkafrawy
  • Danilo Cucchi
  • Kenneth C P Cheung

Colleges, School and Institutes

Abstract

The role of metabolic reprogramming in the coordination of the immune response has gained increasing consideration in recent years. Indeed, it has become clear that changes in the metabolic status of immune cells can alter their functional properties. During inflammation, T cells need to generate sufficient energy and biomolecules to support growth, proliferation, and effector functions. Therefore, T cells need to rearrange their metabolism to meet these demands. A similar metabolic reprogramming has been described in endothelial cells, which have the ability to interact with and modulate the function of immune cells. In this overview, we will discuss recent insights in the complex crosstalk between endothelial cells and T cells as well as their metabolic reprogramming following activation. We highlight key components of this metabolic switch that can lead to the development of new therapeutics against chronic inflammatory disorders.

Bibliographic note

© 2020 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Details

Original languageEnglish
JournalBritish Journal of Pharmacology
Early online date30 Jan 2020
Publication statusE-pub ahead of print - 30 Jan 2020