Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes.

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Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes. / Chong, AY; Freestone, B; Patel, Jeetesh; Lim, Hoong; Hughes, Elizabeth; Blann, Andrew; Lip, Gregory.

In: The American Journal of Cardiology, Vol. 97, No. 5, 01.03.2006, p. 671-5.

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@article{86e794b356e84072afdf0338a5275af4,
title = "Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes.",
abstract = "Congestive heart failure (CHF) is associated with marked endothelial dysfunction. We hypothesized that acute and chronic CHF may manifest different degrees of endothelial damage/dysfunction and activation, as reflected by different plasma endothelial markers, such as von Willebrand factor (vWF) and soluble thrombomodulin (both are indexes of endothelial damage/dysfunction) and soluble E-selectin (an index of endothelial activation). Second, we hypothesized a relation between endothelial markers and B-type natriuretic peptide (BNP, an index of cardiac function) in acute and chronic CHF that could be linked to prognosis. To test this hypothesis, we studied 35 patients with acute CHF, 40 patients with chronic CHF, and 32 healthy controls. The patients with CHF were followed up for the combined outcomes of cardiovascular death, nonfatal myocardial infarction, stroke, thromboembolism, and recurrent admissions to the hospital. vWF (p = 0.001), soluble thrombomodulin, E-selectin, and BNP (all p ",
author = "AY Chong and B Freestone and Jeetesh Patel and Hoong Lim and Elizabeth Hughes and Andrew Blann and Gregory Lip",
year = "2006",
month = mar,
day = "1",
doi = "10.1016/j.amjcard.2005.09.113",
language = "English",
volume = "97",
pages = "671--5",
journal = "The American Journal of cardiology",
issn = "0002-9149",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes.

AU - Chong, AY

AU - Freestone, B

AU - Patel, Jeetesh

AU - Lim, Hoong

AU - Hughes, Elizabeth

AU - Blann, Andrew

AU - Lip, Gregory

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Congestive heart failure (CHF) is associated with marked endothelial dysfunction. We hypothesized that acute and chronic CHF may manifest different degrees of endothelial damage/dysfunction and activation, as reflected by different plasma endothelial markers, such as von Willebrand factor (vWF) and soluble thrombomodulin (both are indexes of endothelial damage/dysfunction) and soluble E-selectin (an index of endothelial activation). Second, we hypothesized a relation between endothelial markers and B-type natriuretic peptide (BNP, an index of cardiac function) in acute and chronic CHF that could be linked to prognosis. To test this hypothesis, we studied 35 patients with acute CHF, 40 patients with chronic CHF, and 32 healthy controls. The patients with CHF were followed up for the combined outcomes of cardiovascular death, nonfatal myocardial infarction, stroke, thromboembolism, and recurrent admissions to the hospital. vWF (p = 0.001), soluble thrombomodulin, E-selectin, and BNP (all p

AB - Congestive heart failure (CHF) is associated with marked endothelial dysfunction. We hypothesized that acute and chronic CHF may manifest different degrees of endothelial damage/dysfunction and activation, as reflected by different plasma endothelial markers, such as von Willebrand factor (vWF) and soluble thrombomodulin (both are indexes of endothelial damage/dysfunction) and soluble E-selectin (an index of endothelial activation). Second, we hypothesized a relation between endothelial markers and B-type natriuretic peptide (BNP, an index of cardiac function) in acute and chronic CHF that could be linked to prognosis. To test this hypothesis, we studied 35 patients with acute CHF, 40 patients with chronic CHF, and 32 healthy controls. The patients with CHF were followed up for the combined outcomes of cardiovascular death, nonfatal myocardial infarction, stroke, thromboembolism, and recurrent admissions to the hospital. vWF (p = 0.001), soluble thrombomodulin, E-selectin, and BNP (all p

U2 - 10.1016/j.amjcard.2005.09.113

DO - 10.1016/j.amjcard.2005.09.113

M3 - Article

C2 - 16490435

VL - 97

SP - 671

EP - 675

JO - The American Journal of cardiology

JF - The American Journal of cardiology

SN - 0002-9149

IS - 5

ER -