Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium

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Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. / MacFadyen, JR; Haworth, OJ; Robertson, D; Hardie, Deborah; Webster, MT; Morris, HR; Panico, M; Sutton-Smith, M; Dell, A; van der Geer, P; Wienke, D; Buckley, Christopher; Isacke, CM.

In: FEBS Letters, Vol. 579, No. 12, 09.05.2005, p. 2569-75.

Research output: Contribution to journalArticle

Harvard

MacFadyen, JR, Haworth, OJ, Robertson, D, Hardie, D, Webster, MT, Morris, HR, Panico, M, Sutton-Smith, M, Dell, A, van der Geer, P, Wienke, D, Buckley, C & Isacke, CM 2005, 'Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium', FEBS Letters, vol. 579, no. 12, pp. 2569-75. https://doi.org/10.1016/j.febslet.2005.03.071

APA

MacFadyen, JR., Haworth, OJ., Robertson, D., Hardie, D., Webster, MT., Morris, HR., Panico, M., Sutton-Smith, M., Dell, A., van der Geer, P., Wienke, D., Buckley, C., & Isacke, CM. (2005). Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Letters, 579(12), 2569-75. https://doi.org/10.1016/j.febslet.2005.03.071

Vancouver

Author

MacFadyen, JR ; Haworth, OJ ; Robertson, D ; Hardie, Deborah ; Webster, MT ; Morris, HR ; Panico, M ; Sutton-Smith, M ; Dell, A ; van der Geer, P ; Wienke, D ; Buckley, Christopher ; Isacke, CM. / Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. In: FEBS Letters. 2005 ; Vol. 579, No. 12. pp. 2569-75.

Bibtex

@article{b58fa5b3b7654ecd843c62e6061b4e0e,
title = "Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium",
abstract = "Fibroblasts are a diverse cell type and display clear topographic differentiation and positional memory. In a screen for fibroblast specific markers we have characterized four monoclonal antibodies to endosialin (TEM1/CD248). Previous studies have reported that endosialin is a tumour endothelium marker and is localized intracellularly. We demonstrate conclusively that endosialin is a cell surface glycoprotein and is predominantly expressed by fibroblasts and a subset of pericytes associated with tumour vessels but not by tumour endothelium. These novel antibodies will facilitate the isolation and classification of fibroblast and pericyte lineages as well as the further functional analysis of endosialin.",
keywords = "TEM, CD248, pericyte, fibroblast, angiogenesis, endosialin",
author = "JR MacFadyen and OJ Haworth and D Robertson and Deborah Hardie and MT Webster and HR Morris and M Panico and M Sutton-Smith and A Dell and {van der Geer}, P and D Wienke and Christopher Buckley and CM Isacke",
year = "2005",
month = may,
day = "9",
doi = "10.1016/j.febslet.2005.03.071",
language = "English",
volume = "579",
pages = "2569--75",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium

AU - MacFadyen, JR

AU - Haworth, OJ

AU - Robertson, D

AU - Hardie, Deborah

AU - Webster, MT

AU - Morris, HR

AU - Panico, M

AU - Sutton-Smith, M

AU - Dell, A

AU - van der Geer, P

AU - Wienke, D

AU - Buckley, Christopher

AU - Isacke, CM

PY - 2005/5/9

Y1 - 2005/5/9

N2 - Fibroblasts are a diverse cell type and display clear topographic differentiation and positional memory. In a screen for fibroblast specific markers we have characterized four monoclonal antibodies to endosialin (TEM1/CD248). Previous studies have reported that endosialin is a tumour endothelium marker and is localized intracellularly. We demonstrate conclusively that endosialin is a cell surface glycoprotein and is predominantly expressed by fibroblasts and a subset of pericytes associated with tumour vessels but not by tumour endothelium. These novel antibodies will facilitate the isolation and classification of fibroblast and pericyte lineages as well as the further functional analysis of endosialin.

AB - Fibroblasts are a diverse cell type and display clear topographic differentiation and positional memory. In a screen for fibroblast specific markers we have characterized four monoclonal antibodies to endosialin (TEM1/CD248). Previous studies have reported that endosialin is a tumour endothelium marker and is localized intracellularly. We demonstrate conclusively that endosialin is a cell surface glycoprotein and is predominantly expressed by fibroblasts and a subset of pericytes associated with tumour vessels but not by tumour endothelium. These novel antibodies will facilitate the isolation and classification of fibroblast and pericyte lineages as well as the further functional analysis of endosialin.

KW - TEM

KW - CD248

KW - pericyte

KW - fibroblast

KW - angiogenesis

KW - endosialin

UR - http://www.scopus.com/inward/record.url?scp=20944451492&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2005.03.071

DO - 10.1016/j.febslet.2005.03.071

M3 - Article

C2 - 15862292

VL - 579

SP - 2569

EP - 2575

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 12

ER -