Endoscopic, rapid near-infrared optical tomography

Research output: Contribution to journalArticlepeer-review


  • Daqing Piao
  • Hao Xie
  • Weili Zhang
  • Jerzy S Krasinski
  • Guolong Zhang
  • Brian W Pogue

Colleges, School and Institutes


This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source-detector fibers for tomography as well as parallel sampling of all source-detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.


Original languageEnglish
Pages (from-to)2876-8
Number of pages3
JournalOptics Letters
Issue number19
Publication statusPublished - 1 Oct 2006


  • Computer Systems, Endoscopes, Equipment Design, Equipment Failure Analysis, Fiber Optic Technology, Image Enhancement, Phantoms, Imaging, Reproducibility of Results, Sensitivity and Specificity, Spectrophotometry, Infrared, Tomography, Optical Coherence