Endogenous glucocorticoids in inflammation: contributions of systemic and local responses

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Endogenous glucocorticoids in inflammation : contributions of systemic and local responses. / Hardy, Rowan S.; Raza, Karim; Cooper, Mark S.

In: Swiss medical weekly, Vol. 142, 2012.

Research output: Contribution to journalReview articlepeer-review

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@article{aa74428968c74db0875bb40bb7d38823,
title = "Endogenous glucocorticoids in inflammation: contributions of systemic and local responses",
abstract = "The anti-inflammatory actions of therapeutic glucocorticoids are well established and these drugs are widely used to treat a variety of inflammatory conditions. It is also clear that endogenously synthesised glucocorticoids have an important role in regulating inflammatory responses. Traditionally, our understanding of the effects of endogenous glucocorticoids has been based on the levels of glucocorticoids within the circulation. These levels are controlled by the hypothalamic-pituitary-adrenal axis. However, more recently it has been established that the local level of glucocorticoids is of potential importance. Situations where the local level of glucocorticoids may differ from the level in the circulation are illustrated in this review. In addition, the mechanisms regulating local glucocorticoid levels and actions are identified. Increasingly, it will be important to understand how the levels of glucocorticoids within the circulation and within the tissues are regulated in a coordinated manner.",
keywords = "inflammation, cortisol, glucocorticoids, 11beta-hydroxysteroid dehydrogenase",
author = "Hardy, {Rowan S.} and Karim Raza and Cooper, {Mark S.}",
year = "2012",
doi = "10.4414/smw.2012.13650",
language = "English",
volume = "142",
journal = "Swiss medical weekly",
issn = "1424-7860",
publisher = "EMH Schweizerischer Arzteverlag",

}

RIS

TY - JOUR

T1 - Endogenous glucocorticoids in inflammation

T2 - contributions of systemic and local responses

AU - Hardy, Rowan S.

AU - Raza, Karim

AU - Cooper, Mark S.

PY - 2012

Y1 - 2012

N2 - The anti-inflammatory actions of therapeutic glucocorticoids are well established and these drugs are widely used to treat a variety of inflammatory conditions. It is also clear that endogenously synthesised glucocorticoids have an important role in regulating inflammatory responses. Traditionally, our understanding of the effects of endogenous glucocorticoids has been based on the levels of glucocorticoids within the circulation. These levels are controlled by the hypothalamic-pituitary-adrenal axis. However, more recently it has been established that the local level of glucocorticoids is of potential importance. Situations where the local level of glucocorticoids may differ from the level in the circulation are illustrated in this review. In addition, the mechanisms regulating local glucocorticoid levels and actions are identified. Increasingly, it will be important to understand how the levels of glucocorticoids within the circulation and within the tissues are regulated in a coordinated manner.

AB - The anti-inflammatory actions of therapeutic glucocorticoids are well established and these drugs are widely used to treat a variety of inflammatory conditions. It is also clear that endogenously synthesised glucocorticoids have an important role in regulating inflammatory responses. Traditionally, our understanding of the effects of endogenous glucocorticoids has been based on the levels of glucocorticoids within the circulation. These levels are controlled by the hypothalamic-pituitary-adrenal axis. However, more recently it has been established that the local level of glucocorticoids is of potential importance. Situations where the local level of glucocorticoids may differ from the level in the circulation are illustrated in this review. In addition, the mechanisms regulating local glucocorticoid levels and actions are identified. Increasingly, it will be important to understand how the levels of glucocorticoids within the circulation and within the tissues are regulated in a coordinated manner.

KW - inflammation

KW - cortisol

KW - glucocorticoids

KW - 11beta-hydroxysteroid dehydrogenase

U2 - 10.4414/smw.2012.13650

DO - 10.4414/smw.2012.13650

M3 - Review article

VL - 142

JO - Swiss medical weekly

JF - Swiss medical weekly

SN - 1424-7860

ER -