Endocrine cells and blood vessels work in tandem to generate hormone pulses

Marie Schaeffer, David J Hodson, Chrystel Lafont, Patrice Mollard

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Hormones are dynamically collected by fenestrated capillaries to generate pulses, which are then decoded by target tissues to mount a biological response. To generate hormone pulses, endocrine systems have evolved mechanisms to tightly regulate blood perfusion and oxygenation, coordinate endocrine cell responses to secretory stimuli, and regulate hormone uptake from the perivascular space into the bloodstream. Based on recent findings, we review here the mechanisms that exist in endocrine systems to regulate blood flow, and facilitate coordinated cell activity and output under both normal physiological and pathological conditions in the pituitary gland and pancreas.

Original languageEnglish
Pages (from-to)R59-66
JournalJournal of Molecular Endocrinology
Volume47
Issue number2
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Animals
  • Endocrine Cells
  • Endocrine System
  • Humans
  • Pancreas
  • Pituitary Gland

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