Emergence of fluoroquinolone resistance in the native Campylobacter coli population of pigs exposed to enrofloxxacin

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Emergence of fluoroquinolone resistance in the native Campylobacter coli population of pigs exposed to enrofloxxacin. / Delsol, A; Sunderland, J; Woodward, M; Pumbwe, Lilian; Piddock, Laura; Roe, J.

In: Journal of Antimicrobial Chemotherapy, Vol. 53, 24.03.2004, p. 872-874.

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@article{6efc379c538446eeb0ffb8c40770d81b,
title = "Emergence of fluoroquinolone resistance in the native Campylobacter coli population of pigs exposed to enrofloxxacin",
abstract = "Objective: The effect of a single 5 day enrofloxacin treatment on the native Campylobacter coli population in conventionally weaned 5-week-old pigs was investigated. Materials: Twelve pigs were split into two groups of six: one group was treated with a therapeutic dose (15 mg/pig/day) of enrofloxacin and the other remained untreated to act as the control. Campylobacter coli were isolated from faecal samples and tested for ciprofloxacin resistance by measuring MIC values. Mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene of resistant isolates were identified by sequencing and denaturing HPLC. Levels of enrofloxacin and its primary metabolite ciprofloxacin in the pig faeces were also measured by HPLC. Results: No quinolone-resistant C. coli (n = 867) were detected in any of the pigs prior to treatment, indicating ",
keywords = "quinolones, animal models, C. coli",
author = "A Delsol and J Sunderland and M Woodward and Lilian Pumbwe and Laura Piddock and J Roe",
year = "2004",
month = mar,
day = "24",
doi = "10.1093/jac/dkh150",
language = "English",
volume = "53",
pages = "872--874",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Emergence of fluoroquinolone resistance in the native Campylobacter coli population of pigs exposed to enrofloxxacin

AU - Delsol, A

AU - Sunderland, J

AU - Woodward, M

AU - Pumbwe, Lilian

AU - Piddock, Laura

AU - Roe, J

PY - 2004/3/24

Y1 - 2004/3/24

N2 - Objective: The effect of a single 5 day enrofloxacin treatment on the native Campylobacter coli population in conventionally weaned 5-week-old pigs was investigated. Materials: Twelve pigs were split into two groups of six: one group was treated with a therapeutic dose (15 mg/pig/day) of enrofloxacin and the other remained untreated to act as the control. Campylobacter coli were isolated from faecal samples and tested for ciprofloxacin resistance by measuring MIC values. Mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene of resistant isolates were identified by sequencing and denaturing HPLC. Levels of enrofloxacin and its primary metabolite ciprofloxacin in the pig faeces were also measured by HPLC. Results: No quinolone-resistant C. coli (n = 867) were detected in any of the pigs prior to treatment, indicating

AB - Objective: The effect of a single 5 day enrofloxacin treatment on the native Campylobacter coli population in conventionally weaned 5-week-old pigs was investigated. Materials: Twelve pigs were split into two groups of six: one group was treated with a therapeutic dose (15 mg/pig/day) of enrofloxacin and the other remained untreated to act as the control. Campylobacter coli were isolated from faecal samples and tested for ciprofloxacin resistance by measuring MIC values. Mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene of resistant isolates were identified by sequencing and denaturing HPLC. Levels of enrofloxacin and its primary metabolite ciprofloxacin in the pig faeces were also measured by HPLC. Results: No quinolone-resistant C. coli (n = 867) were detected in any of the pigs prior to treatment, indicating

KW - quinolones

KW - animal models

KW - C. coli

UR - http://www.scopus.com/inward/record.url?scp=2442685484&partnerID=8YFLogxK

U2 - 10.1093/jac/dkh150

DO - 10.1093/jac/dkh150

M3 - Article

C2 - 15028665

VL - 53

SP - 872

EP - 874

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

ER -