Emergence of fluoroquinolone resistance in the native Campylobacter coli population of pigs exposed to enrofloxxacin

Research output: Contribution to journalArticle


  • A Delsol
  • J Sunderland
  • M Woodward
  • J Roe

Colleges, School and Institutes


Objective: The effect of a single 5 day enrofloxacin treatment on the native Campylobacter coli population in conventionally weaned 5-week-old pigs was investigated. Materials: Twelve pigs were split into two groups of six: one group was treated with a therapeutic dose (15 mg/pig/day) of enrofloxacin and the other remained untreated to act as the control. Campylobacter coli were isolated from faecal samples and tested for ciprofloxacin resistance by measuring MIC values. Mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene of resistant isolates were identified by sequencing and denaturing HPLC. Levels of enrofloxacin and its primary metabolite ciprofloxacin in the pig faeces were also measured by HPLC. Results: No quinolone-resistant C. coli (n = 867) were detected in any of the pigs prior to treatment, indicating


Original languageEnglish
Pages (from-to)872-874
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Early online date24 Mar 2004
Publication statusPublished - 24 Mar 2004


  • quinolones, animal models, C. coli