Elevated CSF leptin in idiopathic intracranial hypertension: evidence for hypothalamic leptin resistance?

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@article{e674f03ae4174551bbaff1a631cc6962,
title = "Elevated CSF leptin in idiopathic intracranial hypertension: evidence for hypothalamic leptin resistance?",
abstract = "Objective: The aetiology of idiopathic intracranial hypertension (IIH) is not known, but its association with obesity is well recognised. Recent studies have linked obesity with abnormalities in circulating inflammatory and adiposity related cytokines. The aim of this study was to characterise adipokine and inflammatory cytokine profiles in IIH. Design: Paired serum and CSF specimens were collected from 26 patients with IIH and compared to 62 control subjects. Samples were analysed for leptin, resistin, adiponectin, insulin, IL-1beta, IL-6, IL-8 (CXCL8), TNFalpha, MCP-1 (CCL2), hepatocyte growth factor, nerve growth factor and PAI-1 using multiplex bead immunoassays. Results: CSF leptin was significantly higher in patients with IIH (p=0.001) compared to controls after correction for age, gender and body mass index (BMI). In the control population, BMI correlated with serum leptin (r = 0.34; p = 0.007) and CSF leptin (r = 0.51; p",
author = "Alexandra Ball and Alexandra Sinclair and Stephen Curnow and Jeremy Tomlinson and Michael Burdon and Elizabeth Walker and Paul Stewart and Peter Nightingale and Carl Clarke and Saaeha Rauz",
year = "2008",
month = sep
day = "1",
doi = "10.1111/j.1365-2265.2008.03401.x",
language = "English",
volume = "70",
pages = "863--869",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Elevated CSF leptin in idiopathic intracranial hypertension: evidence for hypothalamic leptin resistance?

AU - Ball, Alexandra

AU - Sinclair, Alexandra

AU - Curnow, Stephen

AU - Tomlinson, Jeremy

AU - Burdon, Michael

AU - Walker, Elizabeth

AU - Stewart, Paul

AU - Nightingale, Peter

AU - Clarke, Carl

AU - Rauz, Saaeha

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Objective: The aetiology of idiopathic intracranial hypertension (IIH) is not known, but its association with obesity is well recognised. Recent studies have linked obesity with abnormalities in circulating inflammatory and adiposity related cytokines. The aim of this study was to characterise adipokine and inflammatory cytokine profiles in IIH. Design: Paired serum and CSF specimens were collected from 26 patients with IIH and compared to 62 control subjects. Samples were analysed for leptin, resistin, adiponectin, insulin, IL-1beta, IL-6, IL-8 (CXCL8), TNFalpha, MCP-1 (CCL2), hepatocyte growth factor, nerve growth factor and PAI-1 using multiplex bead immunoassays. Results: CSF leptin was significantly higher in patients with IIH (p=0.001) compared to controls after correction for age, gender and body mass index (BMI). In the control population, BMI correlated with serum leptin (r = 0.34; p = 0.007) and CSF leptin (r = 0.51; p

AB - Objective: The aetiology of idiopathic intracranial hypertension (IIH) is not known, but its association with obesity is well recognised. Recent studies have linked obesity with abnormalities in circulating inflammatory and adiposity related cytokines. The aim of this study was to characterise adipokine and inflammatory cytokine profiles in IIH. Design: Paired serum and CSF specimens were collected from 26 patients with IIH and compared to 62 control subjects. Samples were analysed for leptin, resistin, adiponectin, insulin, IL-1beta, IL-6, IL-8 (CXCL8), TNFalpha, MCP-1 (CCL2), hepatocyte growth factor, nerve growth factor and PAI-1 using multiplex bead immunoassays. Results: CSF leptin was significantly higher in patients with IIH (p=0.001) compared to controls after correction for age, gender and body mass index (BMI). In the control population, BMI correlated with serum leptin (r = 0.34; p = 0.007) and CSF leptin (r = 0.51; p

U2 - 10.1111/j.1365-2265.2008.03401.x

DO - 10.1111/j.1365-2265.2008.03401.x

M3 - Article

C2 - 18771566

VL - 70

SP - 863

EP - 869

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

ER -