Electron Capture Dissociation, Electron Detachment Dissociation, and Collision-Induced Dissociation of Polyamidoamine (PAMAM) Dendrimer Ions with Amino, Amidoethanol, and Sodium Carboxylate Surface Groups

Malgorzata Kaczorowska, Helen Cooper

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
148 Downloads (Pure)

Abstract

Here, we investigate the effect of the structure (generation) and nature of the surface groups of different polyamidoamine (PAMAM) dendrimers on electron-mediated dissociation, either electron capture dissociation (ECD) or electron detachment dissociation (EDD), and compare the fragmentation with that observed in collision-induced dissociation (CID). ECD and EDD of the PAMAM dendrimers esulted in simple mass spectra, which are straightforward to interpret, whereas CID produced complex mass spectra. The results show that electron-mediated dissociation (ECD and EDD) of PAMAM dendrimers does not depend on the nature of the surface group but tends to occur within the innermost generations. CID of the PAMAM dendrimers showed a strong dependence on the nature of the surface group and occurred mostly in the outer generation. The results demonstrate the potential utility of ECD and EDD as a tool for the structural analysis of PAMAM dendrimers.
Original languageEnglish
Pages (from-to)1312-1319
Number of pages8
JournalJournal of the American Society for Mass Spectrometry
Volume19
Issue number9
DOIs
Publication statusPublished - 1 Sept 2008

Fingerprint

Dive into the research topics of 'Electron Capture Dissociation, Electron Detachment Dissociation, and Collision-Induced Dissociation of Polyamidoamine (PAMAM) Dendrimer Ions with Amino, Amidoethanol, and Sodium Carboxylate Surface Groups'. Together they form a unique fingerprint.

Cite this