Effects of opioid blockade on nociceptive flexion reflex thresholds and nociceptive responding in hypertensive and normotensive individuals.

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@article{b1c52d21a76249c9b3c8011e15377546,
title = "Effects of opioid blockade on nociceptive flexion reflex thresholds and nociceptive responding in hypertensive and normotensive individuals.",
abstract = "Hypertension and risk for hypertension have been associated with reduced pain sensitivity. It has been hypothesised that endogenous opioids contribute to this hypertensive hypoalgesia. The nociceptive flexion reflex can be used as a tool to investigate modulation of nociceptive transmission at spinal level. The current study employed a double-blind placebo-controlled design to compare the effects of naltrexone, an opioid antagonist, and placebo on nociceptive flexion reflex thresholds and nociceptive responding in unmedicated patients with essential hypertension and normotensive individuals. Neither nociceptive flexion reflex thresholds nor nociceptive responding differed between hypertensives and normotensives during placebo or naltrexone. These data provide no support for the hypothesis that essential hypertension is characterised by higher levels of endogenous opioids in the central nervous system and reveal no association between blood pressure status and nociceptive flexion reflex responses.",
keywords = "endogenous opioids, naltrexone, hypertension, nociceptive flexion reflex threshold, nociceptive responding",
author = "Louisa Edwards and Christopher Ring and CR France and David McIntyre and Una Martin",
year = "2008",
month = aug,
day = "1",
doi = "10.1016/j.ijpsycho.2008.03.005",
language = "English",
volume = "69",
pages = "96--100",
journal = "International journal of psychophysiology : official journal of the International Organization of Psychophysiology",
issn = "0167-8760",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Effects of opioid blockade on nociceptive flexion reflex thresholds and nociceptive responding in hypertensive and normotensive individuals.

AU - Edwards, Louisa

AU - Ring, Christopher

AU - France, CR

AU - McIntyre, David

AU - Martin, Una

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Hypertension and risk for hypertension have been associated with reduced pain sensitivity. It has been hypothesised that endogenous opioids contribute to this hypertensive hypoalgesia. The nociceptive flexion reflex can be used as a tool to investigate modulation of nociceptive transmission at spinal level. The current study employed a double-blind placebo-controlled design to compare the effects of naltrexone, an opioid antagonist, and placebo on nociceptive flexion reflex thresholds and nociceptive responding in unmedicated patients with essential hypertension and normotensive individuals. Neither nociceptive flexion reflex thresholds nor nociceptive responding differed between hypertensives and normotensives during placebo or naltrexone. These data provide no support for the hypothesis that essential hypertension is characterised by higher levels of endogenous opioids in the central nervous system and reveal no association between blood pressure status and nociceptive flexion reflex responses.

AB - Hypertension and risk for hypertension have been associated with reduced pain sensitivity. It has been hypothesised that endogenous opioids contribute to this hypertensive hypoalgesia. The nociceptive flexion reflex can be used as a tool to investigate modulation of nociceptive transmission at spinal level. The current study employed a double-blind placebo-controlled design to compare the effects of naltrexone, an opioid antagonist, and placebo on nociceptive flexion reflex thresholds and nociceptive responding in unmedicated patients with essential hypertension and normotensive individuals. Neither nociceptive flexion reflex thresholds nor nociceptive responding differed between hypertensives and normotensives during placebo or naltrexone. These data provide no support for the hypothesis that essential hypertension is characterised by higher levels of endogenous opioids in the central nervous system and reveal no association between blood pressure status and nociceptive flexion reflex responses.

KW - endogenous opioids

KW - naltrexone

KW - hypertension

KW - nociceptive flexion reflex threshold

KW - nociceptive responding

U2 - 10.1016/j.ijpsycho.2008.03.005

DO - 10.1016/j.ijpsycho.2008.03.005

M3 - Article

C2 - 18436318

VL - 69

SP - 96

EP - 100

JO - International journal of psychophysiology : official journal of the International Organization of Psychophysiology

JF - International journal of psychophysiology : official journal of the International Organization of Psychophysiology

SN - 0167-8760

IS - 2

ER -