Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals

Christopher Ring; CR France; M al'Absi; Louisa Edwards; David McIntyre; Douglas Carroll; Una Martin

doi:10.1016/j.biopsycho.2007.10.006

Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals

Christopher Ring, CR France, M al'Absi, Louisa Edwards, David McIntyre, Douglas Carroll, Una Martin

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.

Original language	English
Pages (from-to)	191-6
Number of pages	6
Journal	Biological Psychology
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/j.biopsycho.2007.10.006
Publication status	Published - 1 Feb 2008

Keywords

endogenous opioids
naltrexone
hypoalgesia
hypertension
pain

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10.1016/j.biopsycho.2007.10.006

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title = "Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals",

abstract = "An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.",

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author = "Christopher Ring and CR France and M al'Absi and Louisa Edwards and David McIntyre and Douglas Carroll and Una Martin",

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AU - Ring, Christopher

AU - France, CR

AU - al'Absi, M

AU - Edwards, Louisa

AU - McIntyre, David

AU - Carroll, Douglas

AU - Martin, Una

PY - 2008/2/1

Y1 - 2008/2/1

N2 - An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.

AB - An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.

KW - endogenous opioids

KW - naltrexone

KW - hypoalgesia

KW - hypertension

KW - pain

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DO - 10.1016/j.biopsycho.2007.10.006

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SP - 191

EP - 196

JO - Biological Psychology

JF - Biological Psychology

IS - 2

ER -

Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals

Abstract

Keywords

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