Effects of emulsifier charge and concentration on pancreatic lipolysis: 2. Interplay of emulsifiers and biles

Research output: Contribution to journalArticlepeer-review

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Effects of emulsifier charge and concentration on pancreatic lipolysis : 2. Interplay of emulsifiers and biles. / Vinarov, Zahari; Tcholakova, Slavka; Damyanova, Borislava; Atanasov, Yasen; Denkov, Nikolai D.; Stoyanov, Simeon D.; Pelan, Edward; Lips, Alex.

In: Langmuir, Vol. 28, No. 33, 21.08.2012, p. 12140-12150.

Research output: Contribution to journalArticlepeer-review

Harvard

Vinarov, Z, Tcholakova, S, Damyanova, B, Atanasov, Y, Denkov, ND, Stoyanov, SD, Pelan, E & Lips, A 2012, 'Effects of emulsifier charge and concentration on pancreatic lipolysis: 2. Interplay of emulsifiers and biles', Langmuir, vol. 28, no. 33, pp. 12140-12150. https://doi.org/10.1021/la301820w

APA

Vinarov, Z., Tcholakova, S., Damyanova, B., Atanasov, Y., Denkov, N. D., Stoyanov, S. D., Pelan, E., & Lips, A. (2012). Effects of emulsifier charge and concentration on pancreatic lipolysis: 2. Interplay of emulsifiers and biles. Langmuir, 28(33), 12140-12150. https://doi.org/10.1021/la301820w

Vancouver

Vinarov Z, Tcholakova S, Damyanova B, Atanasov Y, Denkov ND, Stoyanov SD et al. Effects of emulsifier charge and concentration on pancreatic lipolysis: 2. Interplay of emulsifiers and biles. Langmuir. 2012 Aug 21;28(33):12140-12150. https://doi.org/10.1021/la301820w

Author

Vinarov, Zahari ; Tcholakova, Slavka ; Damyanova, Borislava ; Atanasov, Yasen ; Denkov, Nikolai D. ; Stoyanov, Simeon D. ; Pelan, Edward ; Lips, Alex. / Effects of emulsifier charge and concentration on pancreatic lipolysis : 2. Interplay of emulsifiers and biles. In: Langmuir. 2012 ; Vol. 28, No. 33. pp. 12140-12150.

Bibtex

@article{2a3a864051fe44ad9f6234a1de8c565d,
title = "Effects of emulsifier charge and concentration on pancreatic lipolysis: 2. Interplay of emulsifiers and biles",
abstract = "As a direct continuation of the first part of our in vitro study (Vinarov et al., Langmuir2012, 28, 8127), here we investigate the effects of emulsifier type and concentration on the degree of triglyceride lipolysis, in the presence of bile salts. Three types of surfactants are tested as emulsifiers: anionic, nonionic, and cationic. For all systems, we observe three regions in the dependence degree of fat lipolysis, α, versus emulsifier-to-bile ratio, fs: α is around 0.5 in Region 1 (fs < 0.02); α passes through a maximum close to 1 in Region 2 (0.02 < fs < fTR); α is around zero in Region 3 (fs > fTR). The threshold ratio for complete inhibition of lipolysis, fTR, is around 0.4 for the nonionic, 1.5 for the cationic, and 7.5 for the anionic surfactants. Measurements of interfacial tensions and optical observations revealed the following: In Region 1, the emulsifier molecules are solubilized in the bile micelles, and the adsorption layer is dominated by bile molecules. In Region 2, mixed surfactant-bile micelles are formed, with high solubilization capacity for the products of triglyceride lipolysis; rapid solubilization of these products leads to complete lipolysis. In Region 3, the emulsifier molecules prevail in the adsorption layer and completely block the lipolysis.",
author = "Zahari Vinarov and Slavka Tcholakova and Borislava Damyanova and Yasen Atanasov and Denkov, {Nikolai D.} and Stoyanov, {Simeon D.} and Edward Pelan and Alex Lips",
year = "2012",
month = aug,
day = "21",
doi = "10.1021/la301820w",
language = "English",
volume = "28",
pages = "12140--12150",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "33",

}

RIS

TY - JOUR

T1 - Effects of emulsifier charge and concentration on pancreatic lipolysis

T2 - 2. Interplay of emulsifiers and biles

AU - Vinarov, Zahari

AU - Tcholakova, Slavka

AU - Damyanova, Borislava

AU - Atanasov, Yasen

AU - Denkov, Nikolai D.

AU - Stoyanov, Simeon D.

AU - Pelan, Edward

AU - Lips, Alex

PY - 2012/8/21

Y1 - 2012/8/21

N2 - As a direct continuation of the first part of our in vitro study (Vinarov et al., Langmuir2012, 28, 8127), here we investigate the effects of emulsifier type and concentration on the degree of triglyceride lipolysis, in the presence of bile salts. Three types of surfactants are tested as emulsifiers: anionic, nonionic, and cationic. For all systems, we observe three regions in the dependence degree of fat lipolysis, α, versus emulsifier-to-bile ratio, fs: α is around 0.5 in Region 1 (fs < 0.02); α passes through a maximum close to 1 in Region 2 (0.02 < fs < fTR); α is around zero in Region 3 (fs > fTR). The threshold ratio for complete inhibition of lipolysis, fTR, is around 0.4 for the nonionic, 1.5 for the cationic, and 7.5 for the anionic surfactants. Measurements of interfacial tensions and optical observations revealed the following: In Region 1, the emulsifier molecules are solubilized in the bile micelles, and the adsorption layer is dominated by bile molecules. In Region 2, mixed surfactant-bile micelles are formed, with high solubilization capacity for the products of triglyceride lipolysis; rapid solubilization of these products leads to complete lipolysis. In Region 3, the emulsifier molecules prevail in the adsorption layer and completely block the lipolysis.

AB - As a direct continuation of the first part of our in vitro study (Vinarov et al., Langmuir2012, 28, 8127), here we investigate the effects of emulsifier type and concentration on the degree of triglyceride lipolysis, in the presence of bile salts. Three types of surfactants are tested as emulsifiers: anionic, nonionic, and cationic. For all systems, we observe three regions in the dependence degree of fat lipolysis, α, versus emulsifier-to-bile ratio, fs: α is around 0.5 in Region 1 (fs < 0.02); α passes through a maximum close to 1 in Region 2 (0.02 < fs < fTR); α is around zero in Region 3 (fs > fTR). The threshold ratio for complete inhibition of lipolysis, fTR, is around 0.4 for the nonionic, 1.5 for the cationic, and 7.5 for the anionic surfactants. Measurements of interfacial tensions and optical observations revealed the following: In Region 1, the emulsifier molecules are solubilized in the bile micelles, and the adsorption layer is dominated by bile molecules. In Region 2, mixed surfactant-bile micelles are formed, with high solubilization capacity for the products of triglyceride lipolysis; rapid solubilization of these products leads to complete lipolysis. In Region 3, the emulsifier molecules prevail in the adsorption layer and completely block the lipolysis.

UR - http://www.scopus.com/inward/record.url?scp=84865459851&partnerID=8YFLogxK

U2 - 10.1021/la301820w

DO - 10.1021/la301820w

M3 - Article

C2 - 22680619

AN - SCOPUS:84865459851

VL - 28

SP - 12140

EP - 12150

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 33

ER -