@inproceedings{1c04d42fb69e4f2e80c66173b4cf9835,
title = "Effects of cardiac structural remodelling during heart failure on cardiac excitation - Insights from a heterogeneous 3D model of the rabbit atria",
abstract = "Heart failure is a leading cause of morbidity and mortality in the western world. One of the effects of heart failure is the structural remodelling of cardiac tissue, including tissue dilation and development of fibrosis. It is therefore important to study these changes and their effect on cardiac activity, in order to gain a better understanding of the underlying mechanisms in arrhythmogenesis, which will hopefully enable us to develop better treatments for heart failure. In this study we developed biophysically detailed models of the rabbit atria for normal and heart failure conditions. These models were used to study the effects of structural remodelling of heart failure on cardiac excitation wave conduction. Anatomical reconstructions of the control and heart failure hearts were based on contrast enhanced micro-CT imaging. Fibre orientation was extracted from the control and heart failure datasets. Effects of heart failure geometry on the activation pattern of atrial excitation waves were analyzed. It was found that atrial activation time increased from the control to the heart failure case in both isotropic and anisotropic conditions, which is attributed primarily to the dilation of tissue caused by heart failure.",
author = "Petros Kottas and Colman, {Michael A.} and Stephenson, {Robert S.} and Castro, {Simon J.} and George Hart and Jarvis, {Jonathan C.} and Mark Boyett and Henggui Zhang",
year = "2015",
month = feb,
day = "16",
doi = "10.1109/CIC.2015.7411074",
language = "English",
series = "Computing in Cardiology",
publisher = "IEEE Computer Society",
pages = "969--972",
editor = "Alan Murray",
booktitle = "Computing in Cardiology Conference 2015, CinC 2015",
address = "United States",
note = "42nd Computing in Cardiology Conference, CinC 2015 ; Conference date: 06-09-2015 Through 09-09-2015",
}