Effects of blood pressure lowering drugs in heart failure: a systematic review and meta-analysis of randomised controlled trials

Research output: Contribution to journalArticle

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Effects of blood pressure lowering drugs in heart failure : a systematic review and meta-analysis of randomised controlled trials. / Pinho-Gomes, Ana-Catarina; Azevedo, Luis; Bidel, Zeinab; Nazarzadeh, Milad; Cannoy, Dexter ; Copland, Emma; Salam, Abdul; Rodgers, Anthony ; Kotecha, Dipak; Rahimi, Kazem.

In: Journal of Hypertension, Vol. 37, No. 9, 01.09.2019, p. 1757-1767.

Research output: Contribution to journalArticle

Harvard

Pinho-Gomes, A-C, Azevedo, L, Bidel, Z, Nazarzadeh, M, Cannoy, D, Copland, E, Salam, A, Rodgers, A, Kotecha, D & Rahimi, K 2019, 'Effects of blood pressure lowering drugs in heart failure: a systematic review and meta-analysis of randomised controlled trials', Journal of Hypertension, vol. 37, no. 9, pp. 1757-1767. https://doi.org/10.1097/HJH.0000000000002094

APA

Pinho-Gomes, A-C., Azevedo, L., Bidel, Z., Nazarzadeh, M., Cannoy, D., Copland, E., Salam, A., Rodgers, A., Kotecha, D., & Rahimi, K. (2019). Effects of blood pressure lowering drugs in heart failure: a systematic review and meta-analysis of randomised controlled trials. Journal of Hypertension, 37(9), 1757-1767. https://doi.org/10.1097/HJH.0000000000002094

Vancouver

Author

Pinho-Gomes, Ana-Catarina ; Azevedo, Luis ; Bidel, Zeinab ; Nazarzadeh, Milad ; Cannoy, Dexter ; Copland, Emma ; Salam, Abdul ; Rodgers, Anthony ; Kotecha, Dipak ; Rahimi, Kazem. / Effects of blood pressure lowering drugs in heart failure : a systematic review and meta-analysis of randomised controlled trials. In: Journal of Hypertension. 2019 ; Vol. 37, No. 9. pp. 1757-1767.

Bibtex

@article{b20c8ee257ec4c379e0e097a0d5fa158,
title = "Effects of blood pressure lowering drugs in heart failure: a systematic review and meta-analysis of randomised controlled trials",
abstract = "We aimed to combine evidence from all heart failure trials that have investigated the effects of drugs with blood pressure lowering properties to assess (1) the extent to which such drugs reduce blood pressure in heart failure, (2) the association between the net change in blood pressure between treatment arms and cause-specific outcomes, and (3) whether treatment effects (efficacy and safety) vary according to baseline blood pressure. We conducted a systematic review and meta-analysis including randomised clinical trials of drugs with blood pressure-lowering properties in patients with chronic heart failure with at least 300 patient-years follow-up. We included a total of 37 trials (91,950 patients) and showed that treatment with drugs with blood pressure-lowering properties resulted in a small but significant decrease in systolic blood pressure in patients with heart failure with no evidence that the efficacy and safety of those drugs varied according to baseline blood pressure. Condensed abstract: The relationship between blood pressure and clinical outcomes remains poorly understood. This systematic review and meta-analysis combined evidence from randomised clinical trials of drugs with blood pressure lowering properties in patients with chronic heart failure. It showed that treatment with those drugs achieved a small but significant reduction in systolic blood pressure with no evidence that the efficacy and safety of those drugs varied according to baseline blood pressure. ",
keywords = "Blood Pressure, Hypertension, antihypertensive agent, heart failure, systematic review, Meta-analysis",
author = "Ana-Catarina Pinho-Gomes and Luis Azevedo and Zeinab Bidel and Milad Nazarzadeh and Dexter Cannoy and Emma Copland and Abdul Salam and Anthony Rodgers and Dipak Kotecha and Kazem Rahimi",
year = "2019",
month = sep
day = "1",
doi = "10.1097/HJH.0000000000002094",
language = "English",
volume = "37",
pages = "1757--1767",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Effects of blood pressure lowering drugs in heart failure

T2 - a systematic review and meta-analysis of randomised controlled trials

AU - Pinho-Gomes, Ana-Catarina

AU - Azevedo, Luis

AU - Bidel, Zeinab

AU - Nazarzadeh, Milad

AU - Cannoy, Dexter

AU - Copland, Emma

AU - Salam, Abdul

AU - Rodgers, Anthony

AU - Kotecha, Dipak

AU - Rahimi, Kazem

PY - 2019/9/1

Y1 - 2019/9/1

N2 - We aimed to combine evidence from all heart failure trials that have investigated the effects of drugs with blood pressure lowering properties to assess (1) the extent to which such drugs reduce blood pressure in heart failure, (2) the association between the net change in blood pressure between treatment arms and cause-specific outcomes, and (3) whether treatment effects (efficacy and safety) vary according to baseline blood pressure. We conducted a systematic review and meta-analysis including randomised clinical trials of drugs with blood pressure-lowering properties in patients with chronic heart failure with at least 300 patient-years follow-up. We included a total of 37 trials (91,950 patients) and showed that treatment with drugs with blood pressure-lowering properties resulted in a small but significant decrease in systolic blood pressure in patients with heart failure with no evidence that the efficacy and safety of those drugs varied according to baseline blood pressure. Condensed abstract: The relationship between blood pressure and clinical outcomes remains poorly understood. This systematic review and meta-analysis combined evidence from randomised clinical trials of drugs with blood pressure lowering properties in patients with chronic heart failure. It showed that treatment with those drugs achieved a small but significant reduction in systolic blood pressure with no evidence that the efficacy and safety of those drugs varied according to baseline blood pressure.

AB - We aimed to combine evidence from all heart failure trials that have investigated the effects of drugs with blood pressure lowering properties to assess (1) the extent to which such drugs reduce blood pressure in heart failure, (2) the association between the net change in blood pressure between treatment arms and cause-specific outcomes, and (3) whether treatment effects (efficacy and safety) vary according to baseline blood pressure. We conducted a systematic review and meta-analysis including randomised clinical trials of drugs with blood pressure-lowering properties in patients with chronic heart failure with at least 300 patient-years follow-up. We included a total of 37 trials (91,950 patients) and showed that treatment with drugs with blood pressure-lowering properties resulted in a small but significant decrease in systolic blood pressure in patients with heart failure with no evidence that the efficacy and safety of those drugs varied according to baseline blood pressure. Condensed abstract: The relationship between blood pressure and clinical outcomes remains poorly understood. This systematic review and meta-analysis combined evidence from randomised clinical trials of drugs with blood pressure lowering properties in patients with chronic heart failure. It showed that treatment with those drugs achieved a small but significant reduction in systolic blood pressure with no evidence that the efficacy and safety of those drugs varied according to baseline blood pressure.

KW - Blood Pressure

KW - Hypertension

KW - antihypertensive agent

KW - heart failure

KW - systematic review

KW - Meta-analysis

U2 - 10.1097/HJH.0000000000002094

DO - 10.1097/HJH.0000000000002094

M3 - Article

VL - 37

SP - 1757

EP - 1767

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 9

ER -