Effects of artificial and natural baroreceptor stimulation on nociceptive responding and pain

Louisa Edwards, David McIntyre, Douglas Carroll, Christopher Ring, C France, Una Martin

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The arterial baroreflex may mediate hypertensive hypoalgesia. Carotid baroreceptors can be artificially stimulated by neck suction and inhibited by compression. Effects of brief neck suction and compression on nociceptive responding and pain were studied in 25 normotensive adults. The sural nerve was electrocutaneously stimulated at threshold intensity during systole or diastole combined with neck suction, neck compression, or no pressure. Nociceptive responding was indexed by electromyographic activity elicited in the biceps femoris. Participants rated the intensity of sural stimulation. Although artificial baroreceptor stimulation (suction) did not affect nociceptive responding, baroreceptor inhibition (compression) reduced pain ratings. In contrast, natural baroreceptor stimulation during systole reduced nociceptive responding compared to diastole, but did not affect pain ratings. The data provide partial support for baroreflex modulation of pain.
Original languageEnglish
Pages (from-to)762-769
Number of pages8
JournalPsychophysiology
Volume40
Issue number5
DOIs
Publication statusPublished - 1 Sept 2003

Keywords

  • neck cuff
  • hypertension
  • nociceptive flexion reflex
  • baroreceptors
  • pain
  • cardiac cycle time

Fingerprint

Dive into the research topics of 'Effects of artificial and natural baroreceptor stimulation on nociceptive responding and pain'. Together they form a unique fingerprint.

Cite this