Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul: a randomised controlled superiority trial

Semira Manaseki-Holland, Z Maroof, J Bruce, MZ Mughal, MI Masher, ZA Bhutta, G Walraven, D Chandramohan

    Research output: Contribution to journalArticle

    136 Citations (Scopus)

    Abstract

    Background Vitamin D has a role in regulating immune function, and its deficiency is a suggested risk factor for childhood pneumonia. Our aim was to assess whether oral supplementation of vitamin D-3 (cholecalciferol) will reduce the incidence and severity of pneumonia in a high-risk infant population. Methods We did a randomised placebo-controlled trial to compare oral 100 000 IU (2.5 mg) vitamin D-3 with placebo given to children aged 1-11 months in Kabul, Afghanistan. Randomisation was by use of a computer-generated list. Vitamin D or placebo was given by fieldworkers once every 3 months for 18 months. Children presenting at the study hospital with signs of pneumonia had their diagnosis confirmed radiographically. Our primary outcome was the first or only episode of radiologically confirmed pneumonia. Our analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00548379. Findings 1524 children were assigned to receive vitamin D-3 and 1522 placebo. There was no significant difference between the incidence of first or only pneumonia between the vitamin D (0.145 per child per year, 95% CI 0.129-0.164) and the placebo group (0.137, 0.121-0.155); the incidence rate ratio was 1.06 (95% CI 0.89-1.27). From 652 children during five separate periods of testing serum calcifediol, only one child in each of two testing periods had results greater than 375 nmol/L in the intervention group-a toxic level. Interpretations Quarterly bolus doses of oral vitamin D-3 supplementation to infants are not an effective intervention to reduce the incidence of pneumonia in infants in this setting.
    Original languageEnglish
    Pages (from-to)1419-1427
    Number of pages9
    JournalLancet
    Volume379
    Issue number9824
    DOIs
    Publication statusPublished - 1 Apr 2012

    Fingerprint

    Dive into the research topics of 'Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul: a randomised controlled superiority trial'. Together they form a unique fingerprint.

    Cite this