Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

T J Mitchell, J M Ketley, S C Haslam, J Stephen, D W Burdon, D C Candy, R Daniel

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalGut
Volume27
Issue number1
Publication statusPublished - Jan 1986

Keywords

  • Animals
  • Bacterial Toxins
  • Clostridium
  • Colon
  • Cytotoxins
  • Dose-Response Relationship, Drug
  • Enterotoxins
  • Ileum
  • Male
  • Permeability
  • Rabbits
  • Time Factors

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