Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon
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Colleges, School and Institutes
The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.
|Number of pages||8|
|Publication status||Published - Jan 1986|
- Animals, Bacterial Toxins, Clostridium, Colon, Cytotoxins, Dose-Response Relationship, Drug, Enterotoxins, Ileum, Male, Permeability, Rabbits, Time Factors