Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

Research output: Contribution to journalArticlepeer-review


  • J M Ketley
  • S C Haslam
  • D W Burdon
  • R Daniel

Colleges, School and Institutes


The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.


Original languageEnglish
Pages (from-to)78-85
Number of pages8
Issue number1
Publication statusPublished - Jan 1986


  • Animals, Bacterial Toxins, Clostridium, Colon, Cytotoxins, Dose-Response Relationship, Drug, Enterotoxins, Ileum, Male, Permeability, Rabbits, Time Factors