Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

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Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base. / Martinez, Diego Stéfani T.; Silva, Gabriela H. Da; Medeiros, Aline Maria Z. de; Khan, Latif U.; Papadiamantis, Anastasios G.; Lynch, Iseult.

In: Nanomaterials, Vol. 10, No. 10, 1936, 29.09.2020, p. 1-20.

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@article{e76c2a23bbfe42e48501dfd9192293c5,
title = "Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base",
abstract = "In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the Daphnia magna model and assessing acute toxicity determined as immobilisation. Cadmium (Cd 2+ ) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd 2+ adsorption capacity (ca. 4.5 times) in reconstituted water (Daphnia medium). The acute toxicity values (48 h-EC 50 ) observed were 0.18 mg L −1 for Cd 2+-only and 0.29 and 0.61 mg L −1 following co-exposure of Cd 2+ with GO and BSA@GO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L −1 . After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd 2+-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets. ",
keywords = "Co-exposure, Harmonisation, Nanoecotoxicity, Nanoinformatics, Nanosafety",
author = "Martinez, {Diego St{\'e}fani T.} and Silva, {Gabriela H. Da} and Medeiros, {Aline Maria Z. de} and Khan, {Latif U.} and Papadiamantis, {Anastasios G.} and Iseult Lynch",
year = "2020",
month = sep,
day = "29",
doi = "10.3390/nano10101936",
language = "English",
volume = "10",
pages = "1--20",
journal = "Nanomaterials",
issn = "2079-4991",
publisher = "MDPI",
number = "10",

}

RIS

TY - JOUR

T1 - Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

AU - Martinez, Diego Stéfani T.

AU - Silva, Gabriela H. Da

AU - Medeiros, Aline Maria Z. de

AU - Khan, Latif U.

AU - Papadiamantis, Anastasios G.

AU - Lynch, Iseult

PY - 2020/9/29

Y1 - 2020/9/29

N2 - In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the Daphnia magna model and assessing acute toxicity determined as immobilisation. Cadmium (Cd 2+ ) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd 2+ adsorption capacity (ca. 4.5 times) in reconstituted water (Daphnia medium). The acute toxicity values (48 h-EC 50 ) observed were 0.18 mg L −1 for Cd 2+-only and 0.29 and 0.61 mg L −1 following co-exposure of Cd 2+ with GO and BSA@GO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L −1 . After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd 2+-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.

AB - In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the Daphnia magna model and assessing acute toxicity determined as immobilisation. Cadmium (Cd 2+ ) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd 2+ adsorption capacity (ca. 4.5 times) in reconstituted water (Daphnia medium). The acute toxicity values (48 h-EC 50 ) observed were 0.18 mg L −1 for Cd 2+-only and 0.29 and 0.61 mg L −1 following co-exposure of Cd 2+ with GO and BSA@GO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L −1 . After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd 2+-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.

KW - Co-exposure

KW - Harmonisation

KW - Nanoecotoxicity

KW - Nanoinformatics

KW - Nanosafety

UR - https://doi.org/10.3390/nano10101936

UR - http://www.scopus.com/inward/record.url?scp=85091773723&partnerID=8YFLogxK

U2 - 10.3390/nano10101936

DO - 10.3390/nano10101936

M3 - Article

C2 - 33003330

VL - 10

SP - 1

EP - 20

JO - Nanomaterials

JF - Nanomaterials

SN - 2079-4991

IS - 10

M1 - 1936

ER -