Effect of interstitial low level laser therapy on tibial defect

Research output: Chapter in Book/Report/Conference proceedingConference contribution


  • Sangyeob Lee
  • Myungjin Ha
  • Donghyun Hwang
  • Sungkon Yu
  • Seulki Jang
  • Jihoon Park
  • Hansung Kim
  • Byungjo Jung

Colleges, School and Institutes

External organisations

  • Yonsei University
  • Dept. of Biomedical Engineering


Tibial defect is very common musculoskeletal disorder which makes patient painful and uncomfortable. Many studies about bone regeneration tried to figure out fast bone healing on early phase. It is already known that low level laser therapy (LLLT) is very convenient and good for beginning of bone disorder. However, light scattering and absorption obstruct musculoskeletal therapy which need optimal photon energy delivery. This study has used an interstitial laser probe (ILP) to overcome the limitations of light penetration depth and scattering. Animals (mouse, C57BL/6) were divided into three groups: laser treated test group 1 (660 nm; power 10 mW; total energy 5 J) and test group 2 (660 nm; power 20 mW; total energy 10 J); and untreated control group. All animals were taken surgical operation to make tibial defect on right crest of tibia. The test groups were treated every 48 hours with ILP. Bone volume and X-ray attenuation coefficient were measured on 0, 14th and 28th day with u-CT after treatment and were used to evaluate effect of LLLT. Results show that bone volume of test groups has been improved more than control group. X-ray attenuation coefficients of each groups have slightly different. The results suggest that LLLT combined with ILP may affect on early phase of bone regeneration and may be used in various musculoskeletal disease in deep tissue layer.

Bibliographic note

Publisher Copyright: © 2016 SPIE. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.


Original languageEnglish
Title of host publicationMechanisms of Photobiomodulation Therapy XI
EditorsMichael R. Hamblin, James D. Carroll, Praveen Arany
Publication statusPublished - 2016
EventMechanisms of Photobiomodulation Therapy XI - San Francisco, United States
Duration: 13 Feb 201614 Feb 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMechanisms of Photobiomodulation Therapy XI
CountryUnited States
CitySan Francisco


  • bone, bone regeneration, interstitial laser, laser, LLLT, low-level, tibia