Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency

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Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency. / Gompertz, SM; Hill, AT; Bayley, Darren; Stockley, Robert.

In: Respiratory Medicine, Vol. 100, 01.06.2006, p. 1094-1099.

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Gompertz, SM ; Hill, AT ; Bayley, Darren ; Stockley, Robert. / Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency. In: Respiratory Medicine. 2006 ; Vol. 100. pp. 1094-1099.

Bibtex

@article{a79314a64f9642a79c964210c5286c56,
title = "Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency",
abstract = "It is unclear how chronic expectoration influences airway inflammation in patients with chronic lung disease. The aim of this study was to investigate factors influencing inflammation in induced sputum samples, including, in particular, chronic sputum production. Myeloperoxidase, interleukin-8, leukotriene B4 (LTB4), neutrophil elastase, secretory leukoprotease inhibitor (SLPI) and protein leakage were compared in induced sputum samples from 48 patients (36 with chronic expectoration) with COPD (with and without alpha-1-antitrypsin deficiency; AATD), 9 individuals with AATD but without lung disease and 14 healthy controls. There were no differences in inflammation in induced sputum samples from healthy control subjects and from AATD deficient patients with normal lung function but without chronic expectoration (P>0.05). Inflammation in induced sputum from AATD patients with airflow obstruction and chronic sputum expectoration was significantly greater than for similar patients who did not expectorate: Interleukin-8 (P",
author = "SM Gompertz and AT Hill and Darren Bayley and Robert Stockley",
year = "2006",
month = jun,
day = "1",
doi = "10.1016/j.rmed.2005.09.024",
language = "English",
volume = "100",
pages = "1094--1099",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency

AU - Gompertz, SM

AU - Hill, AT

AU - Bayley, Darren

AU - Stockley, Robert

PY - 2006/6/1

Y1 - 2006/6/1

N2 - It is unclear how chronic expectoration influences airway inflammation in patients with chronic lung disease. The aim of this study was to investigate factors influencing inflammation in induced sputum samples, including, in particular, chronic sputum production. Myeloperoxidase, interleukin-8, leukotriene B4 (LTB4), neutrophil elastase, secretory leukoprotease inhibitor (SLPI) and protein leakage were compared in induced sputum samples from 48 patients (36 with chronic expectoration) with COPD (with and without alpha-1-antitrypsin deficiency; AATD), 9 individuals with AATD but without lung disease and 14 healthy controls. There were no differences in inflammation in induced sputum samples from healthy control subjects and from AATD deficient patients with normal lung function but without chronic expectoration (P>0.05). Inflammation in induced sputum from AATD patients with airflow obstruction and chronic sputum expectoration was significantly greater than for similar patients who did not expectorate: Interleukin-8 (P

AB - It is unclear how chronic expectoration influences airway inflammation in patients with chronic lung disease. The aim of this study was to investigate factors influencing inflammation in induced sputum samples, including, in particular, chronic sputum production. Myeloperoxidase, interleukin-8, leukotriene B4 (LTB4), neutrophil elastase, secretory leukoprotease inhibitor (SLPI) and protein leakage were compared in induced sputum samples from 48 patients (36 with chronic expectoration) with COPD (with and without alpha-1-antitrypsin deficiency; AATD), 9 individuals with AATD but without lung disease and 14 healthy controls. There were no differences in inflammation in induced sputum samples from healthy control subjects and from AATD deficient patients with normal lung function but without chronic expectoration (P>0.05). Inflammation in induced sputum from AATD patients with airflow obstruction and chronic sputum expectoration was significantly greater than for similar patients who did not expectorate: Interleukin-8 (P

UR - http://www.scopus.com/inward/record.url?scp=33646025216&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2005.09.024

DO - 10.1016/j.rmed.2005.09.024

M3 - Article

C2 - 16257194

VL - 100

SP - 1094

EP - 1099

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

ER -