Effect of chyme viscosity and nutrient feedback mechanism on gastric emptying

Research output: Contribution to journalArticle

Authors

  • Philippe Nimmegeers
  • Dries Telen
  • Jan Van Impe

Colleges, School and Institutes

External organisations

  • Department of Chemical Engineering, BioTeC+ & OPTEC, KU Leuven

Abstract

A comprehensive mathematical model of the digestive processes in humans could allow for better design of functional foods which may play a role in stemming the prevalence of food related diseases around the world. This work presents a mathematical model for a nutrient based feedback mechanism controlling gastric emptying, which has been identified in vivo by numerous researchers. The model also takes into account the viscosity of nutrient meals upon gastric secretions and emptying. The results show that modelling the nutrient feedback mechanism as an on/off system, with an initial emptying rate dependent upon the secretion rate (which is a function of the gastric chyme viscosity) provides a good fit to the trends of emptying rate for liquid meals of low and high nutrient content with varying viscosity.

Details

Original languageEnglish
Pages (from-to)318-330
Number of pages13
JournalChemical Engineering Science
Volume171
Early online date30 May 2017
Publication statusPublished - 2 Nov 2017

Keywords

  • Gastric emptying, Gastric secretion, Gastric viscosity, Mathematical modelling, Nutrient feedback mechanism