Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

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Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects. / Salokangas, R. K.R.; Hietala, J.; Armio, R. L.; Laurikainen, H.; From, T.; Borgwardt, S.; Riecher-Rössler, A.; Brambilla, P.; Bonivento, C.; Meisenzahl, E.; Schultze-Lutter, F.; Haidl, T.; Ruhrmann, S.; Upthegrove, R.; Wood, S. J.; Pantelis, C.; Kambeitz-Ilankovic, L.; Ruef, A.; Dwyer, D. B.; Kambeitz, J.; Koutsouleris, N.

In: Schizophrenia Research, 01.05.2020.

Research output: Contribution to journalArticle

Harvard

Salokangas, RKR, Hietala, J, Armio, RL, Laurikainen, H, From, T, Borgwardt, S, Riecher-Rössler, A, Brambilla, P, Bonivento, C, Meisenzahl, E, Schultze-Lutter, F, Haidl, T, Ruhrmann, S, Upthegrove, R, Wood, SJ, Pantelis, C, Kambeitz-Ilankovic, L, Ruef, A, Dwyer, DB, Kambeitz, J & Koutsouleris, N 2020, 'Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects', Schizophrenia Research. https://doi.org/10.1016/j.schres.2020.05.041

APA

Salokangas, R. K. R., Hietala, J., Armio, R. L., Laurikainen, H., From, T., Borgwardt, S., Riecher-Rössler, A., Brambilla, P., Bonivento, C., Meisenzahl, E., Schultze-Lutter, F., Haidl, T., Ruhrmann, S., Upthegrove, R., Wood, S. J., Pantelis, C., Kambeitz-Ilankovic, L., Ruef, A., Dwyer, D. B., ... Koutsouleris, N. (Accepted/In press). Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects. Schizophrenia Research. https://doi.org/10.1016/j.schres.2020.05.041

Vancouver

Author

Salokangas, R. K.R. ; Hietala, J. ; Armio, R. L. ; Laurikainen, H. ; From, T. ; Borgwardt, S. ; Riecher-Rössler, A. ; Brambilla, P. ; Bonivento, C. ; Meisenzahl, E. ; Schultze-Lutter, F. ; Haidl, T. ; Ruhrmann, S. ; Upthegrove, R. ; Wood, S. J. ; Pantelis, C. ; Kambeitz-Ilankovic, L. ; Ruef, A. ; Dwyer, D. B. ; Kambeitz, J. ; Koutsouleris, N. / Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects. In: Schizophrenia Research. 2020.

Bibtex

@article{36e59101270c4b48b9eb3f9e972cfc49,
title = "Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects",
abstract = "Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe.",
keywords = "Amygdala-hippocampus complex, Brain MRI scan, High-risk, Physical abuse, Psychosis, Social anxiety",
author = "Salokangas, {R. K.R.} and J. Hietala and Armio, {R. L.} and H. Laurikainen and T. From and S. Borgwardt and A. Riecher-R{\"o}ssler and P. Brambilla and C. Bonivento and E. Meisenzahl and F. Schultze-Lutter and T. Haidl and S. Ruhrmann and R. Upthegrove and Wood, {S. J.} and C. Pantelis and L. Kambeitz-Ilankovic and A. Ruef and Dwyer, {D. B.} and J. Kambeitz and N. Koutsouleris",
year = "2020",
month = may,
day = "1",
doi = "10.1016/j.schres.2020.05.041",
language = "English",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

AU - Salokangas, R. K.R.

AU - Hietala, J.

AU - Armio, R. L.

AU - Laurikainen, H.

AU - From, T.

AU - Borgwardt, S.

AU - Riecher-Rössler, A.

AU - Brambilla, P.

AU - Bonivento, C.

AU - Meisenzahl, E.

AU - Schultze-Lutter, F.

AU - Haidl, T.

AU - Ruhrmann, S.

AU - Upthegrove, R.

AU - Wood, S. J.

AU - Pantelis, C.

AU - Kambeitz-Ilankovic, L.

AU - Ruef, A.

AU - Dwyer, D. B.

AU - Kambeitz, J.

AU - Koutsouleris, N.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe.

AB - Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe.

KW - Amygdala-hippocampus complex

KW - Brain MRI scan

KW - High-risk

KW - Physical abuse

KW - Psychosis

KW - Social anxiety

UR - http://www.scopus.com/inward/record.url?scp=85085176766&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2020.05.041

DO - 10.1016/j.schres.2020.05.041

M3 - Article

AN - SCOPUS:85085176766

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -