Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

R. K.R. Salokangas; J. Hietala; R. L. Armio; H. Laurikainen; T. From; S. Borgwardt; A. Riecher-Rössler; P. Brambilla; C. Bonivento; E. Meisenzahl; F. Schultze-Lutter; T. Haidl; S. Ruhrmann; R. Upthegrove; S. J. Wood; C. Pantelis; L. Kambeitz-Ilankovic; A. Ruef; D. B. Dwyer; J. Kambeitz; N. Koutsouleris

doi:10.1016/j.schres.2020.05.041

Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

R. K.R. Salokangas^*, J. Hietala, R. L. Armio, H. Laurikainen, T. From, S. Borgwardt, A. Riecher-Rössler, P. Brambilla, C. Bonivento, E. Meisenzahl, F. Schultze-Lutter, T. Haidl, S. Ruhrmann, R. Upthegrove, S. J. Wood, C. Pantelis, L. Kambeitz-Ilankovic, A. Ruef, D. B. Dwyer, J. KambeitzN. Koutsouleris

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood.

Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression.

Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction.

Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe.

Original language	English
Pages (from-to)	101-109
Number of pages	9
Journal	Schizophrenia Research
Volume	227
Early online date	24 May 2020
DOIs	https://doi.org/10.1016/j.schres.2020.05.041
Publication status	Published - Jan 2021

Bibliographical note

Funding:
PRONIA is a Collaborative Project funded by the European Union under the 7th Framework Programme (grant 602152).The study was funded by Turku University Hospital (EVO funding).

The PRONIA study (“Personalised Prognostic Tools for Early Psychosis Management”, ww.pronia.eu) is a Collaboration Project funded by the European Union under the 7th Framework Programme under grant agreement n° 602152.

The work for the manuscript: “Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex in adult clinical high-risk subjects” is also funded by the Turku University Hospital (EVO funding).

Keywords

Amygdala-hippocampus complex
Brain MRI scan
High-risk
Physical abuse
Psychosis
Social anxiety

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2020.05.041Licence: None: All rights reserved

FP7_COLLAB - PRONIA
Upthegrove, R.
European Commission - Management Costs, European Commission
1/10/13 → 31/03/19
Project: Research

Cite this

Salokangas, R. K. R., Hietala, J., Armio, R. L., Laurikainen, H., From, T., Borgwardt, S., Riecher-Rössler, A., Brambilla, P., Bonivento, C., Meisenzahl, E., Schultze-Lutter, F., Haidl, T., Ruhrmann, S., Upthegrove, R., Wood, S. J., Pantelis, C., Kambeitz-Ilankovic, L., Ruef, A., Dwyer, D. B., ... Koutsouleris, N. (2021). Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects. Schizophrenia Research, 227, 101-109. Advance online publication. https://doi.org/10.1016/j.schres.2020.05.041

@article{36e59101270c4b48b9eb3f9e972cfc49,

title = "Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects",

abstract = "Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe.",

keywords = "Amygdala-hippocampus complex, Brain MRI scan, High-risk, Physical abuse, Psychosis, Social anxiety",

author = "Salokangas, {R. K.R.} and J. Hietala and Armio, {R. L.} and H. Laurikainen and T. From and S. Borgwardt and A. Riecher-R{\"o}ssler and P. Brambilla and C. Bonivento and E. Meisenzahl and F. Schultze-Lutter and T. Haidl and S. Ruhrmann and R. Upthegrove and Wood, {S. J.} and C. Pantelis and L. Kambeitz-Ilankovic and A. Ruef and Dwyer, {D. B.} and J. Kambeitz and N. Koutsouleris",

note = "Funding: PRONIA is a Collaborative Project funded by the European Union under the 7th Framework Programme (grant 602152).The study was funded by Turku University Hospital (EVO funding). The PRONIA study (“Personalised Prognostic Tools for Early Psychosis Management”, ww.pronia.eu) is a Collaboration Project funded by the European Union under the 7th Framework Programme under grant agreement n° 602152. The work for the manuscript: “Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex in adult clinical high-risk subjects” is also funded by the Turku University Hospital (EVO funding).",

year = "2021",

month = jan,

doi = "10.1016/j.schres.2020.05.041",

language = "English",

volume = "227",

pages = "101--109",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

}

Salokangas, RKR, Hietala, J, Armio, RL, Laurikainen, H, From, T, Borgwardt, S, Riecher-Rössler, A, Brambilla, P, Bonivento, C, Meisenzahl, E, Schultze-Lutter, F, Haidl, T, Ruhrmann, S, Upthegrove, R , Wood, SJ, Pantelis, C, Kambeitz-Ilankovic, L, Ruef, A, Dwyer, DB, Kambeitz, J & Koutsouleris, N 2021, 'Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects', Schizophrenia Research, vol. 227, pp. 101-109. https://doi.org/10.1016/j.schres.2020.05.041

TY - JOUR

T1 - Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

AU - Salokangas, R. K.R.

AU - Hietala, J.

AU - Armio, R. L.

AU - Laurikainen, H.

AU - From, T.

AU - Borgwardt, S.

AU - Riecher-Rössler, A.

AU - Brambilla, P.

AU - Bonivento, C.

AU - Meisenzahl, E.

AU - Schultze-Lutter, F.

AU - Haidl, T.

AU - Ruhrmann, S.

AU - Upthegrove, R.

AU - Wood, S. J.

AU - Pantelis, C.

AU - Kambeitz-Ilankovic, L.

AU - Ruef, A.

AU - Dwyer, D. B.

AU - Kambeitz, J.

AU - Koutsouleris, N.

N1 - Funding: PRONIA is a Collaborative Project funded by the European Union under the 7th Framework Programme (grant 602152).The study was funded by Turku University Hospital (EVO funding). The PRONIA study (“Personalised Prognostic Tools for Early Psychosis Management”, ww.pronia.eu) is a Collaboration Project funded by the European Union under the 7th Framework Programme under grant agreement n° 602152. The work for the manuscript: “Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex in adult clinical high-risk subjects” is also funded by the Turku University Hospital (EVO funding).

PY - 2021/1

Y1 - 2021/1

N2 - Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe.

AB - Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe.

KW - Amygdala-hippocampus complex

KW - Brain MRI scan

KW - High-risk

KW - Physical abuse

KW - Psychosis

KW - Social anxiety

UR - http://www.scopus.com/inward/record.url?scp=85085176766&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2020.05.041

DO - 10.1016/j.schres.2020.05.041

M3 - Article

AN - SCOPUS:85085176766

SN - 0920-9964

VL - 227

SP - 101

EP - 109

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Projects

FP7_COLLAB - PRONIA

Cite this